@inbook{ce9f4d6877fe49cab648e17d34203e3a,
title = "Testing experimental therapies in a Guinea pig model for hemorrhagic fever",
abstract = "Hemorrhagic fever viruses are among the deadliest pathogens known to humans, and often, licensed medical countermeasures are unavailable to prevent or treat infections. Guinea pigs are a commonly used animal for the preclinical development of any experimental candidates, typically to confirm data generated in mice and as a way to validate and support further testing in nonhuman primates. In this chapter, we use Sudan virus (SUDV), a lethal filovirus closely related to Ebola virus, as an example of the steps required for generating a guinea pig-adapted isolate that is used to test a monoclonal antibody-based therapy against viral hemorrhagic fevers.",
keywords = "Guinea pigs, Hemorrhagic fever, Monoclonal antibodies, Serial passaging, Sudan virus",
author = "Gary Wong and Yuhai Bi and Gary Kobinger and Gao, {George F.} and Xiangguo Qiu",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media LLC 2018.",
year = "2018",
doi = "10.1007/978-1-4939-6981-4_21",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "269--278",
booktitle = "Methods in Molecular Biology",
}