TY - JOUR
T1 - Testosterone Replacement Therapy and Cardiovascular Disease
T2 - Balancing Safety and Risks in Hypogonadal Men
AU - Blackwell, Kelli
AU - Blackwell, Michele
AU - Blackwell, Thomas
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/10
Y1 - 2023/10
N2 - Purpose of Review: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis. Summary: The use of TRT to achieve physiologic testosterone concentrations in men does not pose a threat to CV health and has demonstrated a cardioprotective effect.
AB - Purpose of Review: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis. Summary: The use of TRT to achieve physiologic testosterone concentrations in men does not pose a threat to CV health and has demonstrated a cardioprotective effect.
KW - Cardiovascular disease
KW - Heart
KW - Hypogonadal men
KW - Myocardial infarction
KW - Testosterone
KW - Testosterone replacement therapy
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U2 - 10.1007/s11886-023-01935-1
DO - 10.1007/s11886-023-01935-1
M3 - Review article
C2 - 37733143
AN - SCOPUS:85171773777
SN - 1523-3782
VL - 25
SP - 1157
EP - 1163
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 10
ER -