TY - JOUR
T1 - Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network
T2 - Rationale, design, and baseline characteristics
AU - Trivedi, Madhukar H.
AU - Minhajuddin, Abu
AU - Slater, Holli
AU - Baronia, Regina
AU - Blader, Joseph C.
AU - Blood, Jamon
AU - Brown, Ryan
AU - Claassen, Cynthia
AU - DeFilippis, Melissa
AU - Farmer, David
AU - Garza, Cynthia
AU - Hughes, Jennifer L.
AU - Kennard, Beth D.
AU - Liberzon, Israel
AU - Martin, Sarah
AU - Mayes, Taryn L.
AU - Soares, Jair C.
AU - Soutullo, Cesar A.
AU - Storch, Eric A.
AU - Wakefield, Sarah M.
N1 - Funding Information:
The Texas Youth Depression and Suicide Research Network is a research initiative of the Texas Child Mental Health Care Consortium (TCMHCC) and the Center for Depression Research and Clinical Care of the Peter O'Donnell Jr. Brain Institute at the University of Texas Southwestern Medical Center. The TCMHCC was created by the 86th Texas Legislature and, in part, funds multi-institutional research to improve mental health care for children and adolescents in Texas. The content is solely the responsibility of the authors and does not necessarily represent the official views of the various funding organizations. The funding source had no role in the design, collection, analysis, or interpretation of the data.
Publisher Copyright:
© 2023
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Background: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants. Methods: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school “Nodes” (manage/implement study), each with 1–5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8–20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months. Results: Among 1000 participants, 68.7 % were 12–17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12–17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9). Limitations: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth. Conclusions: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.
AB - Background: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants. Methods: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school “Nodes” (manage/implement study), each with 1–5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8–20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months. Results: Among 1000 participants, 68.7 % were 12–17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12–17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9). Limitations: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth. Conclusions: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.
KW - Collaborative research network
KW - Depression
KW - Suicide
KW - Treatment
KW - Youth
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U2 - 10.1016/j.jad.2023.07.035
DO - 10.1016/j.jad.2023.07.035
M3 - Article
C2 - 37459975
AN - SCOPUS:85150353325
SN - 0165-0327
VL - 340
SP - 88
EP - 99
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -