Th17 cells, Job's syndrome and HIV: Opportunities for bacterial and fungal infections

Joshua D. Milner, Netanya G. Sandler, Daniel C. Douek

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose of review: Patients with hyper IgE syndrome (HIES) share with HIV patients a predisposition to infections, including candidiasis in autosomal dominant HIES (AD-HIES) and molluscum contagiosum and other viral infections in other disorders of elevated IgE with infectious predilections. This review highlights the underlying pathogenesis of these diseases and their relevance to HIV infection. Recent findings: Patients with mutations in STAT3, who lack Th17 cells, develop AD-HIES, whereas other disorders of elevated IgE may be caused by mutations in Tyk2 or DOCK8, the latter of which is associated with decreased expansion of CD8+ more so than CD4+ T cells. Recent studies on patients with recurrent mucocutaneous candidiasis have led to the discovery of mutations in CARD9 and DECTIN-1, genes key to the production of the Th17-driving cytokines IL-1β, IL-6, and IL-23. Studies of the peripheral blood of HIV-positive patients have shown a decreased Th17:Th1 ratio, and Th17 cells were preferentially depleted from the gastrointestinal tract within weeks of simian immunodeficiency virus infection in rhesus macaques. Summary: The consequences of inadequate Th17 production in primary immunodeficiency syndromes illustrate the role of Th17 cells in controlling pathogens to which HIV-positive individuals are susceptible. Further understanding of the pathogenesis of opportunistic disease in HIV infection will probably require exploring the role of Th17 cells.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalCurrent Opinion in HIV and AIDS
Volume5
Issue number2
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Job Syndrome
Th17 Cells
Mycoses
Bacterial Infections
HIV
Candidiasis
Virus Diseases
Immunoglobulin E
Mutation
HIV Infections
Molluscum Contagiosum
Interleukin-23
Simian Immunodeficiency Virus
Th1 Cells
Macaca mulatta
Interleukin-1
Gastrointestinal Tract
Interleukin-6
Cytokines
T-Lymphocytes

Keywords

  • HIV
  • Hyper IgE syndrome
  • Job's syndrome
  • STAT3
  • Th17

ASJC Scopus subject areas

  • Hematology
  • Oncology(nursing)
  • Immunology
  • Infectious Diseases
  • Virology
  • Oncology

Cite this

Th17 cells, Job's syndrome and HIV : Opportunities for bacterial and fungal infections. / Milner, Joshua D.; Sandler, Netanya G.; Douek, Daniel C.

In: Current Opinion in HIV and AIDS, Vol. 5, No. 2, 03.2010, p. 179-183.

Research output: Contribution to journalArticle

Milner, Joshua D. ; Sandler, Netanya G. ; Douek, Daniel C. / Th17 cells, Job's syndrome and HIV : Opportunities for bacterial and fungal infections. In: Current Opinion in HIV and AIDS. 2010 ; Vol. 5, No. 2. pp. 179-183.
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