The 3D Organization of the Yeast Genome Correlates with Co-Expression and Reflects Functional Relations between Genes

Dirar Homouz, Andrzej S. Kudlicki

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The spatial organization of eukaryotic genomes is thought to play an important role in regulating gene expression. The recent advances in experimental methods including chromatin capture techniques, as well as the large amounts of accumulated gene expression data allow studying the relationship between spatial organization of the genome and co-expression of protein-coding genes. To analyse this genome-wide relationship at a single gene resolution, we combined the interchromosomal DNA contacts in the yeast genome measured by Duan et al. with a comprehensive collection of 1,496 gene expression datasets. We find significant enhancement of co-expression among genes with contact links. The co-expression is most prominent when two gene loci fall within 1,000 base pairs from the observed contact. We also demonstrate an enrichment of inter-chromosomal links between functionally related genes, which suggests that the non random nature of the genome organization serves to facilitate coordinated transcription in groups of genes.

Original languageEnglish (US)
Article numbere54699
JournalPLoS One
Volume8
Issue number1
DOIs
StatePublished - Jan 31 2013

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Yeast
Genes
Yeasts
Genome
yeasts
genome
Gene Expression
gene expression
genes
Gene expression
Base Pairing
Chromatin
chromatin
transcription (genetics)
protein synthesis
loci
DNA
Transcription
methodology
Proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The 3D Organization of the Yeast Genome Correlates with Co-Expression and Reflects Functional Relations between Genes. / Homouz, Dirar; Kudlicki, Andrzej S.

In: PLoS One, Vol. 8, No. 1, e54699, 31.01.2013.

Research output: Contribution to journalArticle

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