The ABC of Stem Cell Therapies for Neurological Disorders

Miguel A. Pappolla, Ping Wu, Kumar Sambamurti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Several neurological conditions may result in permanent or progressive injury to the nervous system, and one promising manner to alleviate this damage is through the use of cell-based therapies. Even though many of these treatments are still in the preliminary stages of testing on humans, pre-clinical research has shown encouraging and exciting outcomes. The fundamental principles of stem cell transplantation, such as neurogenesis, neural and mesenchymal stem cells, and their applications to various neurological disorders are discussed in this chapter. These conditions include stroke, traumatic brain injury, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Alzheimer’s disease. The therapeutic potential of these novel approaches to slow down the aging process and lengthen health span is also covered in this chapter. Finally, we address the status of relevant clinical trials in the United States and other countries.

Original languageEnglish (US)
Title of host publicationEssentials of Regenerative Medicine in Interventional Pain Management, Second Edition
PublisherSpringer International Publishing
Pages543-556
Number of pages14
ISBN (Electronic)9783031503573
ISBN (Print)9783031503566
DOIs
StatePublished - Jan 1 2024
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience

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