The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis

Jon Mabley, Francisco Soriano, Pál Pacher, György Haskó, Anita Marton, Rebecca Wallace, Andrew Salzman, Csaba Szabó

    Research output: Contribution to journalArticle

    99 Scopus citations

    Abstract

    This study evaluated the effects of the adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide (IB-MECA), in two murine models of colitis, the dextran sodium sulphate-induced colitis and the spontaneous colitis found in interleukin-10 gene deficient mice. IB-MECA was given orally twice a day at a dose of either 1 or 3 mg/kg/day. Evaluation of colon damage and inflammation was determined grossly (body weight, rectal bleeding) and biochemically (colon levels of myeloperoxidase, malondialdehyde, chemokines and cytokines). There was significantly increased inflammatory cell infiltration into the colon associated with an increase in colon levels of cytokines and chemokines; with subsequent free radical related damage in both dextran sodium sulphate-induced colitis and 10-week-old interleukin-10-/- mice. IB-MECA protected in both models against the colitis induced inflammatory cell infiltration and damage and attenuated the increases in colon inflammatory cytokine and chemokine levels. Thus activation of the adenosine A3 receptor is effective in protecting against colitis.

    Original languageEnglish (US)
    Pages (from-to)323-329
    Number of pages7
    JournalEuropean Journal of Pharmacology
    Volume466
    Issue number3
    DOIs
    StatePublished - Apr 18 2003

    Keywords

    • Adenosine
    • Chemokine
    • Colitis
    • Cytokine

    ASJC Scopus subject areas

    • Pharmacology

    Fingerprint Dive into the research topics of 'The adenosine A<sub>3</sub> receptor agonist, N<sup>6</sup>-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis'. Together they form a unique fingerprint.

  • Cite this