The anabolic response to resistance exercise and a protein-rich meal is not diminished by age

T. B. Symonsi, M. Sheffield-Moore, M. M. Mamerow, R. R. Wolfe, Douglas Paddon-Jones

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Objectives: The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age. Setting: The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas. Participants: Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults. Design: Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum). Measurements: Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 μmol/kg) constant infusion (0.08 μmol•kg-1min1) of L- [ring-13C 6] phenylalanine. Results: Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) %/h, p<0.001] and older adults (pre: 0.075+0.004; post: 0.152+0.017 %/h, p=0.003) following the meal and resistance exercise bout. Conclusion: Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.

Original languageEnglish (US)
Pages (from-to)376-381
Number of pages6
JournalJournal of Nutrition, Health and Aging
Volume15
Issue number5
DOIs
StatePublished - May 2011

Fingerprint

Meals
Exercise
Muscles
Proteins
Muscle Proteins
Eating
Quadriceps Muscle
Phenylalanine
Young Adult
Knee
Healthy Volunteers
Biopsy
Research
Red Meat

Keywords

  • beef
  • diet
  • Nutrition
  • sarcopenia
  • stable isotopes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

The anabolic response to resistance exercise and a protein-rich meal is not diminished by age. / Symonsi, T. B.; Sheffield-Moore, M.; Mamerow, M. M.; Wolfe, R. R.; Paddon-Jones, Douglas.

In: Journal of Nutrition, Health and Aging, Vol. 15, No. 5, 05.2011, p. 376-381.

Research output: Contribution to journalArticle

Symonsi, T. B. ; Sheffield-Moore, M. ; Mamerow, M. M. ; Wolfe, R. R. ; Paddon-Jones, Douglas. / The anabolic response to resistance exercise and a protein-rich meal is not diminished by age. In: Journal of Nutrition, Health and Aging. 2011 ; Vol. 15, No. 5. pp. 376-381.
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abstract = "Objectives: The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age. Setting: The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas. Participants: Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults. Design: Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80{\%} one repetition maximum). Measurements: Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 μmol/kg) constant infusion (0.08 μmol•kg-1min1) of L- [ring-13C 6] phenylalanine. Results: Mixed muscle FSR increased by approximately 108{\%} in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) {\%}/h, p<0.001] and older adults (pre: 0.075+0.004; post: 0.152+0.017 {\%}/h, p=0.003) following the meal and resistance exercise bout. Conclusion: Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.",
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