The aqueous extract of withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats

Kirtikar Shukla, Piyush Dikshit, Rimi Shukla, Jasvinder K. Gambhir

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Withania coagulans fruit has been shown to possess antihyperglycemic properties and is used in the traditional Indian system of medicine. However, there has no systematic study of its mechanism of action. In a rat model diabetes mellitus (DM) was induced by intraperitoneal injection of nicotinamide (230mg/kg of body weight) followed by streptozotocin at 55mg/kg of body weight. After 96h, mildly diabetic (MD) (fasting plasma glucose [FPG]=7-11.1mmol/L) and severely diabetic (SD) (FPG>11.1mmol/L) rats were treated with aqueous extract of W. coagulans fruit at doses of 125, 250, and 500mg/kg of body weight/day orally. FPG, postprandial plasma glucose (PPPG), glycosylated hemoglobin (HbA1c), plasma insulin, tissue glycogen, and glucose-metabolizing enzymes were assayed at Day 30. Treatment of diabetic animals (MD and SD) with different doses of aqueous W. coagulans resulted in significantly decreased FPG, PPPG, and HbA1c (P

Original languageEnglish (US)
Pages (from-to)718-725
Number of pages8
JournalJournal of Medicinal Food
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Withania
Niacinamide
Experimental Diabetes Mellitus
Fruit
Diabetes Mellitus
Glucose
Fasting
Body Weight
Glycosylated Hemoglobin A
Streptozocin
Systems Analysis
Intraperitoneal Injections
Glycogen
Hypoglycemic Agents
Insulin
Enzymes

Keywords

  • antihyperglycemic effect
  • diabetes mellitus
  • glucose-metabolizing enzymes
  • Withania coagulans

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

The aqueous extract of withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats. / Shukla, Kirtikar; Dikshit, Piyush; Shukla, Rimi; Gambhir, Jasvinder K.

In: Journal of Medicinal Food, Vol. 15, No. 8, 01.08.2012, p. 718-725.

Research output: Contribution to journalArticle

Shukla, Kirtikar ; Dikshit, Piyush ; Shukla, Rimi ; Gambhir, Jasvinder K. / The aqueous extract of withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats. In: Journal of Medicinal Food. 2012 ; Vol. 15, No. 8. pp. 718-725.
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