The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB-dependent transcription

Casey Wright, Colin S. Duckett

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Expression and signaling of CD30, a tumor necrosis factor receptor family member, is up-regulated in numerous lymphoid-derived neoplasias, most notably anaplastic large-cell lymphoma (ALCL) and Hodgkin's lymphoma. To gain insight into the mechanism of CD30 signaling, we used an affinity purification strategy that led to the identification of the aryl hydrocarbon receptor nuclear translocator (ARNT) as a CD30-interacting protein that modulated the activity of the RelB subunit of the transcription factor nuclear factor κB (NF-κB). ALCL cells that were deficient in ARNT exhibited defects in RelB recruitment to NF-κB-responsive promoters, whereas RelA recruitment to the same sites was potentiated, resulting in the augmented expression of these NF-κB-responsive genes. These findings indicate that ARNT functions in concert with RelB in a CD30-induced negative feedback mechanism.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalScience
Volume323
Issue number5911
DOIs
StatePublished - Jan 9 2009
Externally publishedYes

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Aryl Hydrocarbon Receptor Nuclear Translocator
Anaplastic Large-Cell Lymphoma
Transcription Factor RelB
Tumor Necrosis Factor Receptors
Hodgkin Disease
Genes
Neoplasms
Proteins

ASJC Scopus subject areas

  • General

Cite this

The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB-dependent transcription. / Wright, Casey; Duckett, Colin S.

In: Science, Vol. 323, No. 5911, 09.01.2009, p. 251-255.

Research output: Contribution to journalArticle

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