The association between serological and dietary vitamin D levels and hepatitis C-related liver disease risk differs in African American and white males

D. L. White, S. Tavakoli-Tabasi, F. Kanwal, D. J. Ramsey, A. Hashmi, J. Kuzniarek, P. Patel, J. Francis, H. B. El-Serag

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Vitamin D may affect the severity of HCV-related liver disease. Aim: To examine the association between serum vitamin D levels and advanced liver disease in a multiethnic US cohort of HCV patients, and account for dietary and supplemental intake. Methods: We measured serum 25-hydroxyvitamin D levels and used FibroSURE-ActiTest to assess hepatic pathology in a cohort of HCV-infected male veterans. We estimated and adjusted for daily intake of vitamin D from diet using a Dietary History Questionnaire, and dispensed prescriptions prior to study enrolment. We used race-stratified logistic regression analyses to evaluate the relationship between serum vitamin D levels and risk of advanced fibrosis (F3/F4-F4) and advanced inflammation (A2/A3-A3). Results: A total of 163 African American (AA) and 126 White non-Hispanics were studied. Overall, ∼44% of AAs and 15% of Whites were vitamin D deficient (<12 ng/mL) or insufficient (12-19 ng/mL); 4% of AAs and 9% of White patients had an elevated level (>50 ng/mL). Among AAs, patients with elevated serum vitamin D levels had significantly higher odds of advanced fibrosis (OR = 12.91, P = 0.03) than those with normal levels. In contrast, AAs with insufficient or deficient levels had > two-fold excess risk of advanced inflammation (P = 0.06). Among White males there was no association between vitamin D levels and advanced fibrosis (F3/F4-F4) or inflammation (A2/A3-A3) risk. Conclusions: We observed potential differences in the association between vitamin D levels and degree of HCV-related hepatic fibrosis between White and African American males. Additional research is necessary to confirm that high serum vitamin D levels may be associated with advanced fibrosis risk in African American males, and to evaluate whether racial differences exist in HCV-infected females.

Original languageEnglish (US)
Pages (from-to)28-37
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Volume38
Issue number1
DOIs
StatePublished - Jul 1 2013

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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    White, D. L., Tavakoli-Tabasi, S., Kanwal, F., Ramsey, D. J., Hashmi, A., Kuzniarek, J., Patel, P., Francis, J., & El-Serag, H. B. (2013). The association between serological and dietary vitamin D levels and hepatitis C-related liver disease risk differs in African American and white males. Alimentary Pharmacology and Therapeutics, 38(1), 28-37. https://doi.org/10.1111/apt.12341