The association between sjögren syndrome and adverse postoperative outcomes

A historical cohort study using administrative health data

Rovnat Babazade, Zhuo Sun, Brian D. Hesler, Arjun Sharma, Natalya Makarova, Jarrod E. Dalton, Alparslan Turan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Sjögren syndrome is a chronic autoimmune disorder of the exocrine glands associated with cardiovascular events. We aimed to evaluate postoperative complications in patients with Sjögren syndrome undergoing noncardiac surgery. Specifically, we tested the primary hypothesis that patients with Sjögren syndrome have a greater risk of postoperative cardiovascular complications than those without the disease. Our secondary hypotheses were that patients with Sjögren syndrome are at greater risk of thromboembolic complications, microcirculatory complications, and mortality. METHODS: We obtained censuses of 2009 to 2010 inpatient hospital discharges across 7 states. Sjögren syndrome was identified by the present-on-admission diagnosis code 710.2. Each Sjögren n syndrome discharge was propensity matched to 4 control discharges. A generalized linear model was used to compare matched Sjögren syndrome patients and controls on risk of in-hospital cardiovascular complications, thromboembolic complications, microcirculatory complications, and mortality. RESULTS: Among 5.5 million qualifying discharges, our final matched sample contained 22,785 matched discharges, including 4557 with Sjögren syndrome. Sixty-six (1.45%) of the matched discharges with Sjögren syndrome and 213 (1.17%) of the matched controls had associated in-hospital cardiovascular complications. The adjusted odds ratio (99% confidence interval) was estimated at 1.14 (0.79-1.64), which was not statistically significant (P = 0.35). There were no sig-nificant differences in the odds of in-hospital thromboembolic complications (1.12 [0.82-1.53]; P = 0.36), in the odds of in-hospital microcirculatory complications (0.98 [0.77-1.26]; P = 0.86), or in the odds of in-hospital mortality (1.11 [0.76-1.61]; P = 0.49). CONCLUSIONS: The presence of Sjögren syndrome does not place patients at an increased risk for postoperative complications or in-hospital mortality.

Original languageEnglish (US)
Pages (from-to)1222-1230
Number of pages9
JournalAnesthesia and Analgesia
Volume121
Issue number5
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

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Cohort Studies
Health
Hospital Mortality
Exocrine Glands
Mortality
Censuses
Inpatients
Linear Models
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The association between sjögren syndrome and adverse postoperative outcomes : A historical cohort study using administrative health data. / Babazade, Rovnat; Sun, Zhuo; Hesler, Brian D.; Sharma, Arjun; Makarova, Natalya; Dalton, Jarrod E.; Turan, Alparslan.

In: Anesthesia and Analgesia, Vol. 121, No. 5, 01.11.2015, p. 1222-1230.

Research output: Contribution to journalArticle

Babazade, Rovnat ; Sun, Zhuo ; Hesler, Brian D. ; Sharma, Arjun ; Makarova, Natalya ; Dalton, Jarrod E. ; Turan, Alparslan. / The association between sjögren syndrome and adverse postoperative outcomes : A historical cohort study using administrative health data. In: Anesthesia and Analgesia. 2015 ; Vol. 121, No. 5. pp. 1222-1230.
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abstract = "BACKGROUND: Sj{\"o}gren syndrome is a chronic autoimmune disorder of the exocrine glands associated with cardiovascular events. We aimed to evaluate postoperative complications in patients with Sj{\"o}gren syndrome undergoing noncardiac surgery. Specifically, we tested the primary hypothesis that patients with Sj{\"o}gren syndrome have a greater risk of postoperative cardiovascular complications than those without the disease. Our secondary hypotheses were that patients with Sj{\"o}gren syndrome are at greater risk of thromboembolic complications, microcirculatory complications, and mortality. METHODS: We obtained censuses of 2009 to 2010 inpatient hospital discharges across 7 states. Sj{\"o}gren syndrome was identified by the present-on-admission diagnosis code 710.2. Each Sj{\"o}gren n syndrome discharge was propensity matched to 4 control discharges. A generalized linear model was used to compare matched Sj{\"o}gren syndrome patients and controls on risk of in-hospital cardiovascular complications, thromboembolic complications, microcirculatory complications, and mortality. RESULTS: Among 5.5 million qualifying discharges, our final matched sample contained 22,785 matched discharges, including 4557 with Sj{\"o}gren syndrome. Sixty-six (1.45{\%}) of the matched discharges with Sj{\"o}gren syndrome and 213 (1.17{\%}) of the matched controls had associated in-hospital cardiovascular complications. The adjusted odds ratio (99{\%} confidence interval) was estimated at 1.14 (0.79-1.64), which was not statistically significant (P = 0.35). There were no sig-nificant differences in the odds of in-hospital thromboembolic complications (1.12 [0.82-1.53]; P = 0.36), in the odds of in-hospital microcirculatory complications (0.98 [0.77-1.26]; P = 0.86), or in the odds of in-hospital mortality (1.11 [0.76-1.61]; P = 0.49). CONCLUSIONS: The presence of Sj{\"o}gren syndrome does not place patients at an increased risk for postoperative complications or in-hospital mortality.",
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AU - Babazade, Rovnat

AU - Sun, Zhuo

AU - Hesler, Brian D.

AU - Sharma, Arjun

AU - Makarova, Natalya

AU - Dalton, Jarrod E.

AU - Turan, Alparslan

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N2 - BACKGROUND: Sjögren syndrome is a chronic autoimmune disorder of the exocrine glands associated with cardiovascular events. We aimed to evaluate postoperative complications in patients with Sjögren syndrome undergoing noncardiac surgery. Specifically, we tested the primary hypothesis that patients with Sjögren syndrome have a greater risk of postoperative cardiovascular complications than those without the disease. Our secondary hypotheses were that patients with Sjögren syndrome are at greater risk of thromboembolic complications, microcirculatory complications, and mortality. METHODS: We obtained censuses of 2009 to 2010 inpatient hospital discharges across 7 states. Sjögren syndrome was identified by the present-on-admission diagnosis code 710.2. Each Sjögren n syndrome discharge was propensity matched to 4 control discharges. A generalized linear model was used to compare matched Sjögren syndrome patients and controls on risk of in-hospital cardiovascular complications, thromboembolic complications, microcirculatory complications, and mortality. RESULTS: Among 5.5 million qualifying discharges, our final matched sample contained 22,785 matched discharges, including 4557 with Sjögren syndrome. Sixty-six (1.45%) of the matched discharges with Sjögren syndrome and 213 (1.17%) of the matched controls had associated in-hospital cardiovascular complications. The adjusted odds ratio (99% confidence interval) was estimated at 1.14 (0.79-1.64), which was not statistically significant (P = 0.35). There were no sig-nificant differences in the odds of in-hospital thromboembolic complications (1.12 [0.82-1.53]; P = 0.36), in the odds of in-hospital microcirculatory complications (0.98 [0.77-1.26]; P = 0.86), or in the odds of in-hospital mortality (1.11 [0.76-1.61]; P = 0.49). CONCLUSIONS: The presence of Sjögren syndrome does not place patients at an increased risk for postoperative complications or in-hospital mortality.

AB - BACKGROUND: Sjögren syndrome is a chronic autoimmune disorder of the exocrine glands associated with cardiovascular events. We aimed to evaluate postoperative complications in patients with Sjögren syndrome undergoing noncardiac surgery. Specifically, we tested the primary hypothesis that patients with Sjögren syndrome have a greater risk of postoperative cardiovascular complications than those without the disease. Our secondary hypotheses were that patients with Sjögren syndrome are at greater risk of thromboembolic complications, microcirculatory complications, and mortality. METHODS: We obtained censuses of 2009 to 2010 inpatient hospital discharges across 7 states. Sjögren syndrome was identified by the present-on-admission diagnosis code 710.2. Each Sjögren n syndrome discharge was propensity matched to 4 control discharges. A generalized linear model was used to compare matched Sjögren syndrome patients and controls on risk of in-hospital cardiovascular complications, thromboembolic complications, microcirculatory complications, and mortality. RESULTS: Among 5.5 million qualifying discharges, our final matched sample contained 22,785 matched discharges, including 4557 with Sjögren syndrome. Sixty-six (1.45%) of the matched discharges with Sjögren syndrome and 213 (1.17%) of the matched controls had associated in-hospital cardiovascular complications. The adjusted odds ratio (99% confidence interval) was estimated at 1.14 (0.79-1.64), which was not statistically significant (P = 0.35). There were no sig-nificant differences in the odds of in-hospital thromboembolic complications (1.12 [0.82-1.53]; P = 0.36), in the odds of in-hospital microcirculatory complications (0.98 [0.77-1.26]; P = 0.86), or in the odds of in-hospital mortality (1.11 [0.76-1.61]; P = 0.49). CONCLUSIONS: The presence of Sjögren syndrome does not place patients at an increased risk for postoperative complications or in-hospital mortality.

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