The association of life’s simple 7 with aldosterone among African Americans in the Jackson heart study

Veena Kesireddy, Yubo Tan, David Kline, Guy Brock, James B. Odei, Bjorn Kluwe, Valery S. Effoe, Justin B.Echouffo Tcheugui, Rita R. Kalyani, Mario Sims, Herman A. Taylor, Morgana Mongraw-Chaffin, Ehimare Akhabue, Joshua J. Joseph

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Among African Americans (AAs), attaining higher levels of American Heart Association (AHA) ideal cardiovascular health (Life’s Simple 7 [LS7]) is associated with lower risk of diabetes and cardiovascular disease (CVD). We previously showed that aldosterone is associated with higher risk of diabetes and CVD in AAs. Thus, we investigated the association of LS7 metrics with aldosterone in the Jackson Heart Study (JHS). Methods: Ideal metrics were defined by AHA 2020 goals for health behaviors (smoking, dietary intake, physical activity, and body mass index) and health factors (total cholesterol, blood pressure, and fasting glucose). The number of ideal LS7 metrics attained at baseline were summed into a continuous score (0–7) and categorical groups (Poor: 0–1, Intermediate: 2–3, and Ideal: ≥4 ideal LS7 metrics). Multivariable linear regression was used. Results: Among 4,095 JHS participants (mean age 55 ± 13 years, 65% female), median serum aldosterone was 4.90, 4.30, and 3.70 ng/dL in the poor (n = 1132), intermediate (n = 2288) and ideal (n = 675) categories respectively. Aldosterone was 15% [0.85 (0.80, 0.90)] and 33% [0.67 (0.61, 0.75)] lower in the intermediate and ideal LS7 categories compared to the poor LS7 category. Each additional LS7 metric attained on continuous LS7 score (0–7) was associated with an 11% [0.89 (0.86, 0.91)] lower aldosterone level with variation by sex with women having a 15% lower aldosterone vs. 5% in men. Conclusions: Higher attainment of ideal LS7 metrics was associated with lower serum aldosterone among AAs with a greater magnitude of association among women compared to men.

Original languageEnglish (US)
Article number955
Issue number5
StatePublished - May 2019
Externally publishedYes


  • African Americans
  • Aldosterone
  • Blood pressure
  • Body mass index
  • Cholesterol
  • Glucose
  • Ideal cardiovascular health
  • Life’s Simple 7
  • Physical activity
  • Smoking

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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