The asymmetric vascular stent

Efficacy in a rabbit aneurysm model

Ciprian N. Ionita, Ann M. Paciorek, Andreea Dohatcu, Kenneth R. Hoffmann, Daniel R. Bednarek, John Kolega, Elad I. Levy, L. Nelson Hopkins, Stephen Rudin, J. Duffy Mocco

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background and Purpose - Development of hemodynamic modifying devices to treat intracranial aneurysms is an active area of research. The asymmetrical vascular stent (AVS), a stent containing a low-porosity patch, is such device. We evaluate AVS efficacy in an in vivo intracranial aneurysm model. Methods - We created 24 elastase rabbit model aneurysms: 13 treated with the AVS, 5 treated with standard coronary stents, and 6 untreated controls. Four weeks after treatment, aneurysms underwent follow-up angiography, cone-beam micro-CT, histological evaluation, and selective electron microscopy scanning. Results - Four rabbits died early in die study: 3 during AVS treatment and 1 control (secondary to intraprocedural vessel injury and an unrelated tumor, respectively). AVS-treated aneurysms exhibited very weak or no aneurysm flow immediately after treatment and no flow in all aneurysms at follow-up. Standard stent-treated aneurysms showed flow both after treatment (5/5) and at follow-up (3/5). All control aneurysms remained patent during the study. Micro-CT scans showed: 9 of 9 scanned AVS aneurysms were occluded, 6 of 9 AVS were ideally placed, and 3 of 9 low-porosity region partially covered the aneurysm neck; standard stent-treated aneurysms were 1 of 5 occluded, 2 of 5 patent, and 2 of 5 partially patent. Histology results demonstrated: for AVS-treated aneurysms, advanced thrombus organization in the (9/9); for standard stent-treated aneurysms, (1/4) no thrombus, (2/4) partially thrombosed, and (1/4) fully thrombosed; for control aneurysms (4/4), no thrombus. Conclusion - The use of AVS shows promise as a viable new therapeutic in intracranial aneurysm treatment. These data encourage further investigation and provide substantial support to the AVS concept.

Original languageEnglish (US)
Pages (from-to)959-965
Number of pages7
JournalStroke
Volume40
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Stents
Aneurysm
Blood Vessels
Rabbits
Thrombosis
Intracranial Aneurysm
Porosity
Therapeutics
Equipment and Supplies
Cone-Beam Computed Tomography
Pancreatic Elastase
Electron Scanning Microscopy
Histology
Angiography
Hemodynamics

Keywords

  • Aneurysm
  • Asymmetrical
  • Elastase
  • Hemodynamics
  • Modification
  • Stent model
  • Vascular

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Ionita, C. N., Paciorek, A. M., Dohatcu, A., Hoffmann, K. R., Bednarek, D. R., Kolega, J., ... Mocco, J. D. (2009). The asymmetric vascular stent: Efficacy in a rabbit aneurysm model. Stroke, 40(3), 959-965. https://doi.org/10.1161/STROKEAHA.108.524124

The asymmetric vascular stent : Efficacy in a rabbit aneurysm model. / Ionita, Ciprian N.; Paciorek, Ann M.; Dohatcu, Andreea; Hoffmann, Kenneth R.; Bednarek, Daniel R.; Kolega, John; Levy, Elad I.; Hopkins, L. Nelson; Rudin, Stephen; Mocco, J. Duffy.

In: Stroke, Vol. 40, No. 3, 03.2009, p. 959-965.

Research output: Contribution to journalArticle

Ionita, CN, Paciorek, AM, Dohatcu, A, Hoffmann, KR, Bednarek, DR, Kolega, J, Levy, EI, Hopkins, LN, Rudin, S & Mocco, JD 2009, 'The asymmetric vascular stent: Efficacy in a rabbit aneurysm model', Stroke, vol. 40, no. 3, pp. 959-965. https://doi.org/10.1161/STROKEAHA.108.524124
Ionita CN, Paciorek AM, Dohatcu A, Hoffmann KR, Bednarek DR, Kolega J et al. The asymmetric vascular stent: Efficacy in a rabbit aneurysm model. Stroke. 2009 Mar;40(3):959-965. https://doi.org/10.1161/STROKEAHA.108.524124
Ionita, Ciprian N. ; Paciorek, Ann M. ; Dohatcu, Andreea ; Hoffmann, Kenneth R. ; Bednarek, Daniel R. ; Kolega, John ; Levy, Elad I. ; Hopkins, L. Nelson ; Rudin, Stephen ; Mocco, J. Duffy. / The asymmetric vascular stent : Efficacy in a rabbit aneurysm model. In: Stroke. 2009 ; Vol. 40, No. 3. pp. 959-965.
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AU - Bednarek, Daniel R.

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