TY - JOUR
T1 - The Banff 2019 Kidney Meeting Report (I)
T2 - Updates on and clarification of criteria for T cell– and antibody-mediated rejection
AU - Loupy, Alexandre
AU - Haas, Mark
AU - Roufosse, Candice
AU - Naesens, Maarten
AU - Adam, Benjamin
AU - Afrouzian, Marjan
AU - Akalin, Enver
AU - Alachkar, Nada
AU - Bagnasco, Serena
AU - Becker, Jan U.
AU - Cornell, Lynn D.
AU - Clahsen-van Groningen, Marian C.
AU - Demetris, Anthony J.
AU - Dragun, Duska
AU - Duong van Huyen, Jean Paul
AU - Farris, Alton B.
AU - Fogo, Agnes B.
AU - Gibson, Ian W.
AU - Glotz, Denis
AU - Gueguen, Juliette
AU - Kikic, Zeljko
AU - Kozakowski, Nicolas
AU - Kraus, Edward
AU - Lefaucheur, Carmen
AU - Liapis, Helen
AU - Mannon, Roslyn B.
AU - Montgomery, Robert A.
AU - Nankivell, Brian J.
AU - Nickeleit, Volker
AU - Nickerson, Peter
AU - Rabant, Marion
AU - Racusen, Lorraine
AU - Randhawa, Parmjeet
AU - Robin, Blaise
AU - Rosales, Ivy A.
AU - Sapir-Pichhadze, Ruth
AU - Schinstock, Carrie A.
AU - Seron, Daniel
AU - Singh, Harsharan K.
AU - Smith, Rex N.
AU - Stegall, Mark D.
AU - Zeevi, Adriana
AU - Solez, Kim
AU - Colvin, Robert B.
AU - Mengel, Michael
N1 - Publisher Copyright:
© 2020 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2020/9/1
Y1 - 2020/9/1
N2 - The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell–mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation.
AB - The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell–mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation.
KW - classification systems: Banff classification
KW - clinical decision-making
KW - clinical research/practice
KW - kidney (allograft) function/dysfunction
KW - kidney transplantation/nephrology
KW - molecular biology: mRNA/mRNA expression
KW - pathology/histopathology
KW - rejection
KW - translational research/science
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U2 - 10.1111/ajt.15898
DO - 10.1111/ajt.15898
M3 - Article
C2 - 32463180
AN - SCOPUS:85085551954
SN - 1600-6135
VL - 20
SP - 2318
EP - 2331
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 9
ER -