The Basic Science of Dupuytren Disease

Andrew Y. Zhang, Jennifer S. Kargel

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Dupuytren disease is a fibroproliferative condition affecting the hands of millions of patients worldwide. The hypothesis of pathogenesis involves genetic factors and internal factors. Recent genome-wide association studies have provided much needed evidence for the long-held belief of a strong genetic component to the pathogenesis of Dupuytren disease. Specifically, abnormal activation of the Wnt signaling pathway plays an important role. Regarding internal factors, microvascular angiopathy and ischemia have been shown to lead to activation of transforming growth factor-β1 and proliferation of myofibroblasts.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalHand Clinics
Issue number3
StatePublished - Aug 2018


  • Dupuytren disease
  • Genetics
  • Growth factors
  • Myofibroblast
  • Pathogenesis
  • Wnt pathway

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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