The Basic Science of Dupuytren Disease

Andrew Y. Zhang, Jennifer S. Kargel

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Dupuytren disease is a fibroproliferative condition affecting the hands of millions of patients worldwide. The hypothesis of pathogenesis involves genetic factors and internal factors. Recent genome-wide association studies have provided much needed evidence for the long-held belief of a strong genetic component to the pathogenesis of Dupuytren disease. Specifically, abnormal activation of the Wnt signaling pathway plays an important role. Regarding internal factors, microvascular angiopathy and ischemia have been shown to lead to activation of transforming growth factor-β1 and proliferation of myofibroblasts.

Original languageEnglish (US)
JournalHand Clinics
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

    Fingerprint

Keywords

  • Dupuytren disease
  • Genetics
  • Growth factors
  • Myofibroblast
  • Pathogenesis
  • Wnt pathway

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this