The benefits of a low dose complex carbohydrate/citrulline electrolyte solution for preoperative carbohydrate loading: Focus on glycemic variability

Barrett A. Kielhorn, Anthony J. Senagore, Theodor Asgeirsson

    Research output: Contribution to journalArticle

    7 Scopus citations


    Background: Perioperative insulin resistance is associated with significant hyperglycemia-related morbidity in patients undergoing major surgery. We sought to assess the effect of preoperative loading with a low-dose maltodextrin/citrulline solution compared to a commercially available sports drink on glycemic levels in an established colorectal enhanced recovery program. Methods: Retrospective analysis was undertaken of elective non-diabetic colectomies and enterectomies from January 2016–March 2017. Cohorts included simple (SIM) and complex carbohydrate (COM) groups. Statistical analysis was performed with linear and logarithmic regression. Results: 83 patients were included (42 SIM, 41 COM). SIM group was older (61.7 vs 52.7 p = 0.012) Glycemic variability was less in the COM group (7.6% vs 21.4% P = 0.034). The frequency of hyperglycemia, postoperative complications, and length of stay trended higher in the SIM group. Conclusions: This retrospective analysis identifies significant improvement in the perioperative glycemic variability with preoperative low dose complex carbohydrate loading compared to simple carbohydrate loading in colorectal surgery patients.

    Original languageEnglish (US)
    Pages (from-to)373-376
    Number of pages4
    JournalAmerican Journal of Surgery
    Issue number3
    StatePublished - Mar 2018



    • Carbohydrate loading
    • Colorectal surgery
    • Enhanced recovery program
    • Perioperative glycemic control

    ASJC Scopus subject areas

    • Surgery

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