The beta-interferon-mediated antimitogenic state resembles the anti-viral state

Mariano Garcia-Blanco, J. A. Porter, E. D. Morrison, C. D. Stiles

Research output: Contribution to journalArticle

Abstract

Much controversy regarding the effect of interferons in control of the animal cell cycle can be reconciled by acknowledging that, until recently, few laboratories enjoyed access to both pure interferons and pure growth-factor preparations. Using such reagents, we show data that suggest the antimitogenic state in Balb/c-3T3 cells by β-interferon resembles the antiviral state in two important regards: dosage and kinetics. Picomolar concentrations of homogeneous β-interferon inhibit the mitogenic response to recombinant platelet-derived growth-factor B chain homodimer. The antimitogenic response is seen only when cells are exposed to pure β-interferon for an extended time prior to platelet-derived growth-factor treatment. The interferon-mediated antimitogenic state is exerted at some point in the cell cycle subsequent to c-myc gene induction.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalOncogene Research
Volume5
Issue number4
StatePublished - 1990
Externally publishedYes

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Keywords

  • β-interferon
  • antimitogenic state
  • c-myc
  • platelet-derived growth factor

ASJC Scopus subject areas

  • Cancer Research

Cite this

Garcia-Blanco, M., Porter, J. A., Morrison, E. D., & Stiles, C. D. (1990). The beta-interferon-mediated antimitogenic state resembles the anti-viral state. Oncogene Research, 5(4), 323-328.