Much controversy regarding the effect of interferons in control of the animal cell cycle can be reconciled by acknowledging that, until recently, few laboratories enjoyed access to both pure interferons and pure growth-factor preparations. Using such reagents, we show data that suggest the antimitogenic state in Balb/c-3T3 cells by β-interferon resembles the antiviral state in two important regards: dosage and kinetics. Picomolar concentrations of homogeneous β-interferon inhibit the mitogenic response to recombinant platelet-derived growth-factor B chain homodimer. The antimitogenic response is seen only when cells are exposed to pure β-interferon for an extended time prior to platelet-derived growth-factor treatment. The interferon-mediated antimitogenic state is exerted at some point in the cell cycle subsequent to c-myc gene induction.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Jan 1 1990|
- antimitogenic state
- platelet-derived growth factor
ASJC Scopus subject areas
- Cancer Research