The C-terminal region of rift valley fever virus NSm protein targets the protein to the mitochondrial outer membrane and exerts antiapoptotic function

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31 Citations (Scopus)

Abstract

The NSm nonstructural protein of Rift Valley fever virus (family Bunyaviridae, genus Phlebovirus) has an antiapoptotic function and affects viral pathogenesis. We found that NSm integrates into the mitochondrial outer membrane and that the protein's N terminus is exposed to the cytoplasm. The C-terminal region of NSm, which contains a basic amino acid cluster and a putative transmembrane domain, targeted the protein to the mitochondrial outer membrane and exerted antiapoptotic function.

Original languageEnglish (US)
Pages (from-to)676-682
Number of pages7
JournalJournal of Virology
Volume87
Issue number1
DOIs
StatePublished - Jan 2013

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Phlebovirus
Rift Valley fever virus
Bunyaviridae
Basic Amino Acids
Mitochondrial Membranes
Membrane Proteins
Cytoplasm
Proteins
proteins
pathogenesis
cytoplasm
amino acids
Protein Domains
mitochondrial membrane

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

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abstract = "The NSm nonstructural protein of Rift Valley fever virus (family Bunyaviridae, genus Phlebovirus) has an antiapoptotic function and affects viral pathogenesis. We found that NSm integrates into the mitochondrial outer membrane and that the protein's N terminus is exposed to the cytoplasm. The C-terminal region of NSm, which contains a basic amino acid cluster and a putative transmembrane domain, targeted the protein to the mitochondrial outer membrane and exerted antiapoptotic function.",
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