The calf model of immunity for development of a vaccine against tuberculosis

Janice J. Endsley, W. Ray Waters, Mitchell V. Palmer, Brian J. Nonnecke, Tyler C. Thacker, William R. Jacobs, Michelle H. Larsen, Alison Hogg, Elisabeth Shell, Martin McAlauy, Charles F.Capinosh Scherer, Tracey Coffey, Chris J. Howard, Bernardo Villareal-Ramos, D. Mark Estes

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Tuberculosis (TB) remains a major threat to public health. The identification of safe TB vaccine candidates beyond Mycobacterium bovis BCG, is an exciting prospect for control of human TB and necessary in the context of the human immunodeficiency virus (HIV) pandemic. Selection of vaccine candidates for human trials which are ultimately targeted for use in children less than 5 years of age or in newborns will require an animal model that closely approximates immune function and disease. We propose that the bovine neonate and adolescent is a robust animal model for preclinical safety and efficacy evaluation of TB candidate vaccines targeting this special human population. Parallel studies conducted in bovine neonates and non-human primates with a leading auxotrophic mutant with demonstrated efficacy/safety in a rodent TB model of TB demonstrated similar findings with respect to gross pathology scoring relative to BCG. The findings indicated more numerous and severe lesions in the lung in addition to higher levels of IFN-gamma producing cells. BCG vaccinates demonstrated higher levels of FoxP3 transcripts and lower levels of IL-4 mRNA.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalVeterinary Immunology and Immunopathology
Volume128
Issue number1-3
DOIs
StatePublished - Mar 15 2009

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Keywords

  • Tuberculosis
  • markers
  • neonatal calf
  • prognostic

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Endsley, J. J., Waters, W. R., Palmer, M. V., Nonnecke, B. J., Thacker, T. C., Jacobs, W. R., Larsen, M. H., Hogg, A., Shell, E., McAlauy, M., Scherer, C. F. C., Coffey, T., Howard, C. J., Villareal-Ramos, B., & Estes, D. M. (2009). The calf model of immunity for development of a vaccine against tuberculosis. Veterinary Immunology and Immunopathology, 128(1-3), 199-204. https://doi.org/10.1016/j.vetimm.2008.10.312