The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology

Raquel Das Neves Almeida; Heloisa Antoniella Braz-De-Melo; Igor De Oliveira Santos; Rafael Corrêa; Gary P. Kobinger; Kelly Grace Magalhaes

doi:10.3390/cells9041006

The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology

Raquel Das Neves Almeida, Heloisa Antoniella Braz-De-Melo, Igor De Oliveira Santos, Rafael Corrêa, Gary P. Kobinger, Kelly Grace Magalhaes

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Zika virus (ZIKV) has been reported by several groups as an important virus causing pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular somatic and germ cells, as well as spermatozoa, leading to cell death and testicular atrophy. ZIKV has also been detected in semen samples from ZIKV-infected patients. This has huge implications for human reproduction. Global scientific efforts are being applied to understand the mechanisms related to arboviruses persistency, pathogenesis, and host cellular response to suggest a potential target to develop robust antiviral therapeutics and vaccines. Here, we discuss the cellular modulation of the immunologic and physiologic properties of the male reproductive tract environment caused by arboviruses infection, focusing on ZIKV.We also present an overview of the current vaccine effects and therapeutic targets against ZIKV infection that may impact the testis and male fertility.

Original language	English (US)
Article number	1006
Journal	Cells
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/cells9041006
State	Published - Apr 2020
Externally published	Yes

Keywords

Arboviruses
Infertility
Leydig cells
Sertoli cells
ZIKA virus

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells9041006

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title = "The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology",

abstract = "Zika virus (ZIKV) has been reported by several groups as an important virus causing pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular somatic and germ cells, as well as spermatozoa, leading to cell death and testicular atrophy. ZIKV has also been detected in semen samples from ZIKV-infected patients. This has huge implications for human reproduction. Global scientific efforts are being applied to understand the mechanisms related to arboviruses persistency, pathogenesis, and host cellular response to suggest a potential target to develop robust antiviral therapeutics and vaccines. Here, we discuss the cellular modulation of the immunologic and physiologic properties of the male reproductive tract environment caused by arboviruses infection, focusing on ZIKV.We also present an overview of the current vaccine effects and therapeutic targets against ZIKV infection that may impact the testis and male fertility.",

keywords = "Arboviruses, Infertility, Leydig cells, Sertoli cells, ZIKA virus",

author = "Almeida, {Raquel Das Neves} and Braz-De-Melo, {Heloisa Antoniella} and Santos, {Igor De Oliveira} and Rafael Corr{\^e}a and Kobinger, {Gary P.} and Magalhaes, {Kelly Grace}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = apr,

doi = "10.3390/cells9041006",

language = "English (US)",

volume = "9",

journal = "Cells",

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T1 - The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology

AU - Almeida, Raquel Das Neves

AU - Braz-De-Melo, Heloisa Antoniella

AU - Santos, Igor De Oliveira

AU - Corrêa, Rafael

AU - Kobinger, Gary P.

AU - Magalhaes, Kelly Grace

PY - 2020/4

Y1 - 2020/4

N2 - Zika virus (ZIKV) has been reported by several groups as an important virus causing pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular somatic and germ cells, as well as spermatozoa, leading to cell death and testicular atrophy. ZIKV has also been detected in semen samples from ZIKV-infected patients. This has huge implications for human reproduction. Global scientific efforts are being applied to understand the mechanisms related to arboviruses persistency, pathogenesis, and host cellular response to suggest a potential target to develop robust antiviral therapeutics and vaccines. Here, we discuss the cellular modulation of the immunologic and physiologic properties of the male reproductive tract environment caused by arboviruses infection, focusing on ZIKV.We also present an overview of the current vaccine effects and therapeutic targets against ZIKV infection that may impact the testis and male fertility.

AB - Zika virus (ZIKV) has been reported by several groups as an important virus causing pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular somatic and germ cells, as well as spermatozoa, leading to cell death and testicular atrophy. ZIKV has also been detected in semen samples from ZIKV-infected patients. This has huge implications for human reproduction. Global scientific efforts are being applied to understand the mechanisms related to arboviruses persistency, pathogenesis, and host cellular response to suggest a potential target to develop robust antiviral therapeutics and vaccines. Here, we discuss the cellular modulation of the immunologic and physiologic properties of the male reproductive tract environment caused by arboviruses infection, focusing on ZIKV.We also present an overview of the current vaccine effects and therapeutic targets against ZIKV infection that may impact the testis and male fertility.

KW - Arboviruses

KW - Infertility

KW - Leydig cells

KW - Sertoli cells

KW - ZIKA virus

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DO - 10.3390/cells9041006

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JO - Cells

JF - Cells

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M1 - 1006

ER -

The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology

Abstract

Keywords

ASJC Scopus subject areas

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