The circadian periodicity of urinary 17 ketosteroids, corticosteroids, and electrolytes in congenital adrenal hyperplasia

Walter Meyer, E. C. Diller, F. C. Bartter, F. Halberg

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The circadian periodicity of adrenal function in patients with congenital virilizing adrenal hyperplasia (CAH) was examined by measuring the urinary 17 ketosteroids, 17 hydroxycorticosteroids, sodium, and potassium. Patients with the salt losing and the non salt losing types were fitted to the data by the least squares method to determine the mesors, amplitudes, and acrophases of the variable for each patient. The data reveal distinct circadian rhythms for all variables measured whether or not the patient was receiving treatment. The acrophases for 17 ketosteroid and 17 hydroxycorticosteroids were between 1500 and 1800 h. These acrophases are about 6 h later than those for normal subjects. The treatment on a fixed daytime schedule for many years may have shifted the natural rhythm.

Original languageEnglish (US)
Pages (from-to)1122-1127
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number5
StatePublished - 1976
Externally publishedYes

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17-Hydroxycorticosteroids
17-Ketosteroids
Congenital Adrenal Hyperplasia
Periodicity
Electrolytes
Adrenal Cortex Hormones
Salts
Potassium
Sodium
Circadian Rhythm
Least-Squares Analysis
Appointments and Schedules
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The circadian periodicity of urinary 17 ketosteroids, corticosteroids, and electrolytes in congenital adrenal hyperplasia. / Meyer, Walter; Diller, E. C.; Bartter, F. C.; Halberg, F.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 43, No. 5, 1976, p. 1122-1127.

Research output: Contribution to journalArticle

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