The combined use of local irradiation and Corynebacterium parvum in the treatment of the murine line 1 lung carcinoma

R. L. Ullrich, L. M. Adams

Research output: Contribution to journalArticle

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Abstract

The effectiveness of Corynebacterium parvum in combination with local irradiation has been examined in the treatment of the murine line 1 lung carcinoma, a highly radioresistant, weakly immunogenic tumor that kills the host by means of metastatic spread. Sixteen-week-old, specific-pathogen-free female BALB/c mice were given 106 tumor cells im into the right thigh. Tumors were irradiated on Day 7 after transplant. Those receiving C. parvum treatment were given 0.1 mg either by the intralesional (il), ip, or iv route on Day 4 after transplant or by the il or ip route on Day 8. An additional group received C. parvum ip once a week for 4 weeks beginning on Day 8. The influence of the various treatments on local control and metastasis was assessed. To evaluate further the time course and incidence of metastases, cleared lungs were examined at 21, 28, and 35 days in groups given irradiation combined with C. parvum on day 8. C. parvum was more effective in facilitating local control and inhibiting metastatic spread when given after radiation exposure rather than before.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalRadiation Research
Volume73
Issue number2
StatePublished - 1978
Externally publishedYes

Fingerprint

Propionibacterium acnes
Corynebacterium
metastasis
lungs
carcinoma
tumors
irradiation
cancer
Carcinoma
Lung
neoplasms
mice
thighs
routes
thigh
pathogens
radiation dosage
incidence
Neoplasm Metastasis
Transplants

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

The combined use of local irradiation and Corynebacterium parvum in the treatment of the murine line 1 lung carcinoma. / Ullrich, R. L.; Adams, L. M.

In: Radiation Research, Vol. 73, No. 2, 1978, p. 267-273.

Research output: Contribution to journalArticle

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N2 - The effectiveness of Corynebacterium parvum in combination with local irradiation has been examined in the treatment of the murine line 1 lung carcinoma, a highly radioresistant, weakly immunogenic tumor that kills the host by means of metastatic spread. Sixteen-week-old, specific-pathogen-free female BALB/c mice were given 106 tumor cells im into the right thigh. Tumors were irradiated on Day 7 after transplant. Those receiving C. parvum treatment were given 0.1 mg either by the intralesional (il), ip, or iv route on Day 4 after transplant or by the il or ip route on Day 8. An additional group received C. parvum ip once a week for 4 weeks beginning on Day 8. The influence of the various treatments on local control and metastasis was assessed. To evaluate further the time course and incidence of metastases, cleared lungs were examined at 21, 28, and 35 days in groups given irradiation combined with C. parvum on day 8. C. parvum was more effective in facilitating local control and inhibiting metastatic spread when given after radiation exposure rather than before.

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