@article{5563b5300f8f428ba40dc1d7e8939e93,
title = "THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview",
abstract = "The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified {\textquoteleft}Other protein targets{\textquoteright} which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.",
author = "{CGTP Collaborators} and Alexander, {Stephen P.H.} and Eamonn Kelly and Marrion, {Neil V.} and Peters, {John A.} and Elena Faccenda and Harding, {Simon D.} and Pawson, {Adam J.} and Sharman, {Joanna L.} and Christopher Southan and Buneman, {O. Peter} and Cidlowski, {John A.} and Arthur Christopoulos and Davenport, {Anthony P.} and Doriano Fabbro and Michael Spedding and J{\"o}rg Striessnig and Davies, {Jamie A.} and Abbracchio, {M. P.} and R. Aldrich and K. Al-Hosaini and Arumugam, {T. V.} and B. Attali and M. B{\"a}ck and Barnes, {N. M.} and R. Bathgate and Beart, {P. M.} and E. Becirovic and B. Bettler and M. Biel and Birdsall, {N. J.} and V. Blaho and D. Boison and H. Br{\"a}uner-osborne and S. Br{\"o}er and C. Bryant and G. Burnstock and G. Calo and Catterall, {W. A.} and S. Ceruti and Chan, {S. L.} and Chandy, {K. G.} and P. Chazot and N. Chiang and Chun, {J. J.} and Chung, {J. J.} and Clapham, {D. E.} and L. Clapp and Connor, {M. A.} and A. Papapetropoulos and C. Szabo",
note = "Funding Information: We are extremely grateful to the British Pharmacological Society and the International Union of Basic and Clinical Pharmacology, for financial support of the website and for advice from the NC-IUPHAR subcommittees. We thank the University of Edinburgh, who host the www.guidetopharmacology.org website. Previously, the International Union of Basic and Clinical Pharmacology and the Wellcome Trust (099156/Z/12/Z]) also supported the initiation and expansion of the database. We are also tremendously grateful to the long list of collaborators from NC-IUPHAR subcommittees and beyond, who have assisted in the construction of the Concise Guide to PHARMACOLOGY 2017/18 and the online database www.GuideToPHARMACOLOGY.org. Further, we wish to thank Toni Wigglesworth for her assistance in the co-ordination of correspondence with these collaborators. Publisher Copyright: {\textcopyright} 2017 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.",
year = "2017",
month = dec,
doi = "10.1111/bph.13882",
language = "English (US)",
volume = "174",
pages = "S1--S16",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "John Wiley and Sons Inc.",
}