The crucial role of biofilms in Cryptococcus neoformans survival within macrophages and colonization of the central nervous system

Lilit Aslanyan, David A. Sanchez, Silvana Valdebenito, Eliseo A. Eugenin, Raddy L. Ramos, Luis R. Martinez

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life threatening meningoencephalitis in patients with impaired immunity. This microbe primarily infects the host via inhalation but has the ability to disseminate to the central nervous system (CNS) either as a single cell or inside of macrophages. Upon traversing the blood brain barrier, C. neoformans has the capacity to form biofilm-like structures known as cryptococcomas. Hence, we will discuss the C. neoformans elements contributing to biofilm formation including the fungus’ ability to survive in the acidic environment of a macrophage phagosome and inside of the CNS. The purpose of this mini-review is to instill fresh interest in understanding the importance of biofilms on fungal pathogenesis.

Original languageEnglish (US)
Article number10
JournalJournal of Fungi
Volume3
Issue number1
DOIs
StatePublished - Mar 2017

Keywords

  • Biofilms
  • CNS
  • Cryptococcomas
  • Cryptococcus neoformans
  • Macrophages

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)

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