The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation

Michael L. Kueht, Laxmi Priya Dongur, Matthew Cusick, Heather L. Stevenson, Muhammad Mujtaba

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Renal transplantation is the definitive therapy for patients suffering from end-stage renal disease. Though there have been significant advances in immunosuppression in these patients, there is still up to 30% acute and subclinical rejection. Current standards employ lab markers of renal function and biopsy results for accurate diagnosis. However, donor derived cell-free DNA has been identified as a measurable lab test that may be able to adequately diagnose rejection at early stages, precluding the need for invasive procedures like biopsy. We obtained published data directly from companies that offer ddcfDNA assay tests and additionally conducted a literature review using databases like PUBMED and NIH U.S. National Library of Medicine. We comprehensively compare the most used ddcfDNA assays, delineate their respective limitations, and further explore future directions in the utility of ddcfDNA in renal transplant patients.

Original languageEnglish (US)
Article number1700
JournalJournal of Personalized Medicine
Volume12
Issue number10
DOIs
StatePublished - Oct 2022

Keywords

  • T-cell mediated rejection
  • antibody-mediated rejection
  • do-nor-derived cell-free DNA
  • renal transplantation

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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