The development and genetic diversity of H5N1 influenza virus in China, 1996-2006

L. Duan, J. Bahl, G. J.D. Smith, J. Wang, D. Vijaykrishna, L. J. Zhang, J. X. Zhang, K. S. Li, X. H. Fan, C. L. Cheung, Kai Huang, L. L.M. Poon, K. F. Shortridge, R. G. Webster, J. S.M. Peiris, H. Chen, Y. Guan

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.

Original languageEnglish (US)
Pages (from-to)243-254
Number of pages12
JournalVirology
Volume380
Issue number2
DOIs
StatePublished - Oct 25 2008
Externally publishedYes

Fingerprint

H5N1 Subtype Influenza A Virus
Orthomyxoviridae
China
Genotype
Geese
Genome

Keywords

  • Avian influenza
  • Genotype
  • Reassortant

ASJC Scopus subject areas

  • Virology

Cite this

Duan, L., Bahl, J., Smith, G. J. D., Wang, J., Vijaykrishna, D., Zhang, L. J., ... Guan, Y. (2008). The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology, 380(2), 243-254. https://doi.org/10.1016/j.virol.2008.07.038

The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. / Duan, L.; Bahl, J.; Smith, G. J.D.; Wang, J.; Vijaykrishna, D.; Zhang, L. J.; Zhang, J. X.; Li, K. S.; Fan, X. H.; Cheung, C. L.; Huang, Kai; Poon, L. L.M.; Shortridge, K. F.; Webster, R. G.; Peiris, J. S.M.; Chen, H.; Guan, Y.

In: Virology, Vol. 380, No. 2, 25.10.2008, p. 243-254.

Research output: Contribution to journalArticle

Duan, L, Bahl, J, Smith, GJD, Wang, J, Vijaykrishna, D, Zhang, LJ, Zhang, JX, Li, KS, Fan, XH, Cheung, CL, Huang, K, Poon, LLM, Shortridge, KF, Webster, RG, Peiris, JSM, Chen, H & Guan, Y 2008, 'The development and genetic diversity of H5N1 influenza virus in China, 1996-2006', Virology, vol. 380, no. 2, pp. 243-254. https://doi.org/10.1016/j.virol.2008.07.038
Duan L, Bahl J, Smith GJD, Wang J, Vijaykrishna D, Zhang LJ et al. The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology. 2008 Oct 25;380(2):243-254. https://doi.org/10.1016/j.virol.2008.07.038
Duan, L. ; Bahl, J. ; Smith, G. J.D. ; Wang, J. ; Vijaykrishna, D. ; Zhang, L. J. ; Zhang, J. X. ; Li, K. S. ; Fan, X. H. ; Cheung, C. L. ; Huang, Kai ; Poon, L. L.M. ; Shortridge, K. F. ; Webster, R. G. ; Peiris, J. S.M. ; Chen, H. ; Guan, Y. / The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. In: Virology. 2008 ; Vol. 380, No. 2. pp. 243-254.
@article{804ff26addea440d9a5213e772bfc10f,
title = "The development and genetic diversity of H5N1 influenza virus in China, 1996-2006",
abstract = "Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.",
keywords = "Avian influenza, Genotype, Reassortant",
author = "L. Duan and J. Bahl and Smith, {G. J.D.} and J. Wang and D. Vijaykrishna and Zhang, {L. J.} and Zhang, {J. X.} and Li, {K. S.} and Fan, {X. H.} and Cheung, {C. L.} and Kai Huang and Poon, {L. L.M.} and Shortridge, {K. F.} and Webster, {R. G.} and Peiris, {J. S.M.} and H. Chen and Y. Guan",
year = "2008",
month = "10",
day = "25",
doi = "10.1016/j.virol.2008.07.038",
language = "English (US)",
volume = "380",
pages = "243--254",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - The development and genetic diversity of H5N1 influenza virus in China, 1996-2006

AU - Duan, L.

AU - Bahl, J.

AU - Smith, G. J.D.

AU - Wang, J.

AU - Vijaykrishna, D.

AU - Zhang, L. J.

AU - Zhang, J. X.

AU - Li, K. S.

AU - Fan, X. H.

AU - Cheung, C. L.

AU - Huang, Kai

AU - Poon, L. L.M.

AU - Shortridge, K. F.

AU - Webster, R. G.

AU - Peiris, J. S.M.

AU - Chen, H.

AU - Guan, Y.

PY - 2008/10/25

Y1 - 2008/10/25

N2 - Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.

AB - Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.

KW - Avian influenza

KW - Genotype

KW - Reassortant

UR - http://www.scopus.com/inward/record.url?scp=53249130653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53249130653&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2008.07.038

DO - 10.1016/j.virol.2008.07.038

M3 - Article

VL - 380

SP - 243

EP - 254

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -