The distribution and prevalence of group A arbovirus neutralizing antibodies among human populations in Southeast Asia and the Pacific islands

R. B. Tesh, D. C. Gajdusek, R. M. Garruto, J. H. Cross, L. Rosen

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Plaque reduction neutralization tests, using five group A arboviruses (chikungunya, Ross River, Getah, Bebaru and Sindbis), were done on sera from human populations in 44 Southeast Asia and Pacific island localities. Specificity of the plaque neutralization test was determined by examining convalescent sera from patients with known alphavirus infections. Chikungunya specific neutralizing antibodies were demonstrated in sera of persons living in South Vietnam, Northern Malaysia, Indonesia (Kalimantan and Sulawesi), as well as Luzon, Marinduque, Cebu and Mindanao islands in the Philippines. Evidence of Ross River virus infection was found among populations living in West New Guinea and Papua New Guinea mainland, the Bismark Archipelago, Rossel Island and the Solomon Islands. There appeared to be no geographic overlap in the distribution of chikungunya and Ross River viruses, with the separation in their distribution corresponding with Weber's line in the Pacific. Sindbis neutralizing antibodies were found in 7 of 21 populations sampled, but in general the prevalence of infection was low. Four sera, from Vietnam, Malaysia and Mindanao gave monospecific reactions with Getah virus. No evidence of specific Bebaru virus infection was detected. The epidemiology of these five alphaviruses in Southeast Asia and the Pacific islands is discussed.

Original languageEnglish (US)
Pages (from-to)664-675
Number of pages12
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume24
Issue number4
StatePublished - 1975
Externally publishedYes

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Pacific Islands
Alphavirus
Southeastern Asia
Neutralizing Antibodies
Indonesia
Ross River virus
Neutralization Tests
Vietnam
Malaysia
Virus Diseases
Serum
Islands
Population
Alphavirus Infections
Melanesia
Papua New Guinea
Philippines
Rivers
Epidemiology
Infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

The distribution and prevalence of group A arbovirus neutralizing antibodies among human populations in Southeast Asia and the Pacific islands. / Tesh, R. B.; Gajdusek, D. C.; Garruto, R. M.; Cross, J. H.; Rosen, L.

In: American Journal of Tropical Medicine and Hygiene, Vol. 24, No. 4, 1975, p. 664-675.

Research output: Contribution to journalArticle

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