The distribution of fatty acid ethyl esters among lipoproteins and albumin in human serum

David A. Bird, Ayman Kabakibi, Michael Laposata

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Fatty acid ethyl asters (FAEEs) are nonoxidative products of ethanol metabolism and have been implicated as mediators of ethanol-induced organ damage. Previous studies have demonstrated that FAEEs bind to lipoproteins and albumin in human plasma after ethanol ingestion. Analysis of human serum with varying blood ethanol fevers and endogenously formed FAEEs revealed a positive correlation between serum FAEE concentration and the percentage of FAEEs associated with lipoproteins, predominantly very low density and low density lipoprotein. Similar results were obtained when increasing amounts of FAEEs were added to serum with zero blood ethanol. Additional studies indicated that free fatty acids and FAEEs do not compete for binding to albumin or lipoproteins. Data support the conclusion that the distribution of FAEEs among their carriers in the serum is dependent on serum FAEE concentration.

Original languageEnglish (US)
Pages (from-to)602-605
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume21
Issue number4
DOIs
StatePublished - Jan 1 1997

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Keywords

  • Ethanol
  • FAEE
  • Fatty Acids
  • Lipids
  • Lipoprotein

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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