The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Robert W. Cross, Chad E. Mire, Viktoriya Borisevich, Joan B. Geisbert, Karla A. Fenton, Thomas W. Geisbert

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Small-animal models have been developed for several Filoviridae species; however, serial adaptation was required to produce lethal infection. These adapted viruses have sequence changes in several genes, including those that modulate the host immune response. Nonhuman primate models do not require adaptation of filoviruses. Here, we describe lethal models of disease for Bundibugyo, Sudan, and Zaire species of Ebolavirus in the domestic ferret, using wild-type nonadapted viruses. Pathologic features were consistent with disease in primates. Of particular importance, this is the only known small-animal model developed for Bundibugyo and the only uniformly lethal animal model for Bundibugyo.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalJournal of Infectious Diseases
Issue number4
StatePublished - Aug 15 2016


  • Adaptation
  • Animal model
  • Coagulopathy
  • Ebola virus
  • Ferret
  • Filovirus
  • Pathogenesis
  • Permeability
  • Therapeutics
  • Vaccines
  • Virulence

ASJC Scopus subject areas

  • General Medicine


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