The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

Gijs A. Versteeg, Ricardo Rajsbaum Gorodezky, Maria Teresa Sánchez-Aparicio, Ana M. Maestre, Julio Valdiviezo, Mude Shi, Kyung Soo Inn, Ana Fernandez-Sesma, Jae Jung, Adolfo García-Sastre

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have been implicated in modulation of innate immunity and anti-microbial activity. Here we report the complementary DNA cloning and systematic analysis of all known 75 human TRIMs. We demonstrate that roughly half of the 75 TRIM-family members enhanced the innate immune response and that they do this at multiple levels in signaling pathways. Moreover, messenger RNA levels and localization of most of these TRIMs were found to be altered during viral infection, suggesting that their regulatory activities are highly controlled at both pre- and posttranscriptional levels. Taken together, our data demonstrate a very considerable dedication of this large protein family to the positive regulation of the antiviral response, which supports the notion that this family of proteins evolved as a component of innate immunity.

Original languageEnglish (US)
Pages (from-to)384-398
Number of pages15
JournalImmunity
Volume38
Issue number2
DOIs
StatePublished - Feb 21 2013
Externally publishedYes

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Pattern Recognition Receptors
Ubiquitin-Protein Ligases
Innate Immunity
Antiviral Agents
Interferon Type I
Anniversaries and Special Events
Virus Diseases
Organism Cloning
Proteins
Complementary DNA
Messenger RNA
Tripartite Motif Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Versteeg, G. A., Rajsbaum Gorodezky, R., Sánchez-Aparicio, M. T., Maestre, A. M., Valdiviezo, J., Shi, M., ... García-Sastre, A. (2013). The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors. Immunity, 38(2), 384-398. https://doi.org/10.1016/j.immuni.2012.11.013

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors. / Versteeg, Gijs A.; Rajsbaum Gorodezky, Ricardo; Sánchez-Aparicio, Maria Teresa; Maestre, Ana M.; Valdiviezo, Julio; Shi, Mude; Inn, Kyung Soo; Fernandez-Sesma, Ana; Jung, Jae; García-Sastre, Adolfo.

In: Immunity, Vol. 38, No. 2, 21.02.2013, p. 384-398.

Research output: Contribution to journalArticle

Versteeg, GA, Rajsbaum Gorodezky, R, Sánchez-Aparicio, MT, Maestre, AM, Valdiviezo, J, Shi, M, Inn, KS, Fernandez-Sesma, A, Jung, J & García-Sastre, A 2013, 'The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors', Immunity, vol. 38, no. 2, pp. 384-398. https://doi.org/10.1016/j.immuni.2012.11.013
Versteeg, Gijs A. ; Rajsbaum Gorodezky, Ricardo ; Sánchez-Aparicio, Maria Teresa ; Maestre, Ana M. ; Valdiviezo, Julio ; Shi, Mude ; Inn, Kyung Soo ; Fernandez-Sesma, Ana ; Jung, Jae ; García-Sastre, Adolfo. / The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors. In: Immunity. 2013 ; Vol. 38, No. 2. pp. 384-398.
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