The effect of 17β-estradiol on isolated omental arteries from preeclamptic women

Yuri P. Vedernikov, George Saade, Michael A. Belfort, Tony S. Wen, Robert E. Garfield

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To study the effect of 17β-estradiol on isolated omental arteries from preeclamptic women. Study Design: Rings of omental artery with intact endothelium were mounted in organ chambers for isometric tension recording. We studied the effect of pharmacological concentrations of 17β-estradiol on potassium chloride-induced tension and the concentration-contraction relationships for norepinephrine and calcium. Results: Cumulative application of 17β-estradiol, in a concentration-dependent manner, relaxed potassium chloride contracted rings. Sixty minutes of incubation with 17β-estradiol (10-5mol/l) attenuated the tension developed in response to potassium chloride, norepinephrine and calcium. Tamoxifen (10-6mol/l) did not antagonize the inhibitory actions of 17β-estradiol. Conclusions: Pharmacological concentrations of 17β-estradiol retain the capability for relaxing omental artery rings from preeclamptic women. The loss of refractoriness to norepinephrine, increased responsiveness to calcium ions and decreased ability of 17β-estradiol to inhibit calcium-induced tension may be responsible for increased vascular reactivity in preeclampsia.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume95
Issue number1
DOIs
StatePublished - 2001

Fingerprint

Estradiol
Arteries
Potassium Chloride
Calcium
Norepinephrine
Pharmacology
Tamoxifen
Pre-Eclampsia
Endothelium
Blood Vessels
Ions

Keywords

  • 17β-Estradiol
  • Calcium channel inhibition
  • Human omental artery
  • Preeclampsia
  • Tamoxifen

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

The effect of 17β-estradiol on isolated omental arteries from preeclamptic women. / Vedernikov, Yuri P.; Saade, George; Belfort, Michael A.; Wen, Tony S.; Garfield, Robert E.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 95, No. 1, 2001, p. 46-51.

Research output: Contribution to journalArticle

Vedernikov, Yuri P. ; Saade, George ; Belfort, Michael A. ; Wen, Tony S. ; Garfield, Robert E. / The effect of 17β-estradiol on isolated omental arteries from preeclamptic women. In: European Journal of Obstetrics Gynecology and Reproductive Biology. 2001 ; Vol. 95, No. 1. pp. 46-51.
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