Abstract
Objective: To study the effect of 17β-estradiol on isolated omental arteries from preeclamptic women. Study Design: Rings of omental artery with intact endothelium were mounted in organ chambers for isometric tension recording. We studied the effect of pharmacological concentrations of 17β-estradiol on potassium chloride-induced tension and the concentration-contraction relationships for norepinephrine and calcium. Results: Cumulative application of 17β-estradiol, in a concentration-dependent manner, relaxed potassium chloride contracted rings. Sixty minutes of incubation with 17β-estradiol (10 -5 mol/l) attenuated the tension developed in response to potassium chloride, norepinephrine and calcium. Tamoxifen (10 -6 mol/l) did not antagonize the inhibitory actions of 17β-estradiol. Conclusions: Pharmacological concentrations of 17β-estradiol retain the capability for relaxing omental artery rings from preeclamptic women. The loss of refractoriness to norepinephrine, increased responsiveness to calcium ions and decreased ability of 17β-estradiol to inhibit calcium-induced tension may be responsible for increased vascular reactivity in preeclampsia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 46-51 |
| Number of pages | 6 |
| Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
| Volume | 95 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
Keywords
- 17β-Estradiol
- Calcium channel inhibition
- Human omental artery
- Preeclampsia
- Tamoxifen
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology