The effect of 17β-estradiol on isolated omental arteries from preeclamptic women

Yuri P. Vedernikov, George R. Saade, Michael A. Belfort, Tony S. Wen, Robert E. Garfield

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To study the effect of 17β-estradiol on isolated omental arteries from preeclamptic women. Study Design: Rings of omental artery with intact endothelium were mounted in organ chambers for isometric tension recording. We studied the effect of pharmacological concentrations of 17β-estradiol on potassium chloride-induced tension and the concentration-contraction relationships for norepinephrine and calcium. Results: Cumulative application of 17β-estradiol, in a concentration-dependent manner, relaxed potassium chloride contracted rings. Sixty minutes of incubation with 17β-estradiol (10 -5 mol/l) attenuated the tension developed in response to potassium chloride, norepinephrine and calcium. Tamoxifen (10 -6 mol/l) did not antagonize the inhibitory actions of 17β-estradiol. Conclusions: Pharmacological concentrations of 17β-estradiol retain the capability for relaxing omental artery rings from preeclamptic women. The loss of refractoriness to norepinephrine, increased responsiveness to calcium ions and decreased ability of 17β-estradiol to inhibit calcium-induced tension may be responsible for increased vascular reactivity in preeclampsia.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume95
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • 17β-Estradiol
  • Calcium channel inhibition
  • Human omental artery
  • Preeclampsia
  • Tamoxifen

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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