The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates

J. Palecek, V. Neugebauer, S. M. Carlton, S. Iyengar, W. D. Willis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The responses of antidromically identified spinothalamic tract (STT) neurons to mechanical and thermal stimuli were compared in anesthetized normal and neuropathic monkeys before and after administration of a GluR5 kainate receptor antagonist (LY382884) into the spinal cord dorsal horn through a microdialysis fiber. Peripheral neuropathy was induced by tight ligation of the L7 spinal nerve 13-15 days prior to the experiment. STT neurons recorded in the animals with neuropathy showed increased responsiveness to weak mechanical stimuli and to heating and cooling of the skin compared to STT cells in normal animals. In both normal and the neuropathic monkeys the responses of the STT neurons to mechanical and thermal stimuli were attenuated by LY382884 application in a concentration-dependent manner. Intraspinal application of LY382884 in the neuropathic animals led to a potent reduction of those responses of the STT neurons that were aggravated by the peripheral neuropathy (weak mechanical, heat and innocuous cooling stimuli). These results suggest that kainate receptors are involved in synaptic activation of STT cells in the normal state and may also play an important role in pathological pain states such as peripheral neuropathy in primates. Kainate receptor antagonists could thus be useful for the treatment of certain forms of allodynia and hyperalgesia.

Original languageEnglish (US)
Pages (from-to)151-161
Number of pages11
JournalPain
Volume111
Issue number1-2
DOIs
StatePublished - Sep 2004

Fingerprint

Spinothalamic Tracts
Peripheral Nervous System Diseases
LY382884
Primates
Neurons
Kainic Acid Receptors
Hot Temperature
Hyperalgesia
Haplorhini
Spinal Nerves
Microdialysis
Heating
Ligation
Gluk1 kainate receptor
Pain
Skin

Keywords

  • Kainate receptor
  • Peripheral neuropathy
  • Primate
  • Spinothalamic tract neuron

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates. / Palecek, J.; Neugebauer, V.; Carlton, S. M.; Iyengar, S.; Willis, W. D.

In: Pain, Vol. 111, No. 1-2, 09.2004, p. 151-161.

Research output: Contribution to journalArticle

Palecek, J. ; Neugebauer, V. ; Carlton, S. M. ; Iyengar, S. ; Willis, W. D. / The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates. In: Pain. 2004 ; Vol. 111, No. 1-2. pp. 151-161.
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