The effect of activated factor VII for intracerebral hemorrhage beyond 3 hours versus within 3 hours

Hen Hallevi, Nicole R. Gonzales, Andrew D. Barreto, Sheryl Martin-Schild, Karen C. Albright, Elizabeth A. Noser, Kachi Illoh, Aslam M. Khaja, Teresa Allison, Miguel A. Escobar, Hashem Shaltoni, James C. Grotta

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9 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Recombinant-activated factor VII (rFVIIa) is an investigational treatment for intracerebral hemorrhage (ICH). We have evaluated the drug's treatment effect based on time to treatment. METHODS - ICH patients treated up to 4 hours from symptom onset were divided based on time to treatment: ≤3 hours (3H) and 3 to 4 hours (4H). Head CT was done at baseline and 24 hours. Outcome measures included: ICH growth at 24 hours, mortality, favorable outcome and discharge disposition. A cohort of nontreated matched ICH patients was used to asses the clinical efficacy. RESULTS - Forty-six patients were treated with rFVIIa: 24 in the 3H group (range 70 to 180 minutes), 22 in the 4H group (range 181 to 300). One hundred and forty-eight patients formed the control group. Mean baseline ICH volume was 8.8 mL for 3H and 10.1 mL for 4H. Mean 24-hour volume was 9.3 mL for 3H (absolute increase 1.05 mL, relative increase 11.9%) and 11.5 mL for 4H (absolute increase 1.1 mL, relative increase 10.9%); P=0.47 is for the difference in relative increase. Mortality was 12.5% for 3H group, 13.6% for 4H, and 13.1% for the control. In the 3H group, 58.3% were discharged with a poor outcome, compared with 54.5% in 4H and 54.1% in the control. Thrombotic adverse events occurred in 11.1% of patients treated with rFVIIa. CONCLUSIONS - In our off-label with rFVIIa, we did not find evidence of a treatment effect based on time to treatment. Other criteria should be sought to identify patients who might benefit clinically from rFVIIa.

Original languageEnglish (US)
Pages (from-to)473-475
Number of pages3
JournalStroke
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

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Keywords

  • Hematoma growth
  • Intracerebral hemorrhage
  • Recombinant-activated factor VII

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Hallevi, H., Gonzales, N. R., Barreto, A. D., Martin-Schild, S., Albright, K. C., Noser, E. A., Illoh, K., Khaja, A. M., Allison, T., Escobar, M. A., Shaltoni, H., & Grotta, J. C. (2008). The effect of activated factor VII for intracerebral hemorrhage beyond 3 hours versus within 3 hours. Stroke, 39(2), 473-475. https://doi.org/10.1161/STROKEAHA.107.497651