The effect of acute volume expansion and vasodilatation with verapamil on uterine and umbilical artery Doppler indices in severe preeclampsia

M. Belfort, K. Akovic, J. Anthony, George Saade, B. Kirshon, K. Moise

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Preeclampsia is associated with increased peripheral, uterine, and umbilical artery resistance. Acute blood pressure reduction may result in shunting of blood and sudden fetal distress. We therefore investigated the effects of volume expansion and verapamil therapy on uteroplacental and umbilical resistance during treatment of preeclampsia. Materials and Methods: Five severe preeclamptics underwent volume expansion and subsequent vasodilatation with an infusion of verapamil. Invasive hemodynamic monitoring and Doppler ultrasonography were used to study changes in maternal, uterine, and umbilical hemodynamics. Results: Volume expansion and subsequent verapamil therapy was associated with significant changes in maternal hemodynamics without significant change in uteroplacental or umbilical resistance. Uterine artery waveform changes were noted, with disappearance of notching in some cases. Conclusions: Volume expansion and verapamil therapy effectively reduces maternal blood pressure in preeclampsia, without adversely affecting uteroplacental or umbilical artery resistance. Uterine artery waveform changes may be associated with improved fetal outcome.

Original languageEnglish (US)
Pages (from-to)317-325
Number of pages9
JournalJournal of Clinical Ultrasound
Volume22
Issue number5
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Uterine Artery
Umbilical Arteries
Verapamil
arteries
Pre-Eclampsia
Umbilicus
Vasodilation
hemodynamics
blood pressure
therapy
expansion
Hemodynamics
Mothers
waveforms
Blood Pressure
Doppler Ultrasonography
Fetal Distress
pressure reduction
blood
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

The effect of acute volume expansion and vasodilatation with verapamil on uterine and umbilical artery Doppler indices in severe preeclampsia. / Belfort, M.; Akovic, K.; Anthony, J.; Saade, George; Kirshon, B.; Moise, K.

In: Journal of Clinical Ultrasound, Vol. 22, No. 5, 1994, p. 317-325.

Research output: Contribution to journalArticle

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AU - Saade, George

AU - Kirshon, B.

AU - Moise, K.

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