The effect of acute volume expansion and vasodilatation with verapamil on uterine and umbilical artery Doppler indices in severe preeclampsia

M. Belfort, K. Akovic, J. Anthony, G. Saade, B. Kirshon, K. Moise

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Preeclampsia is associated with increased peripheral, uterine, and umbilical artery resistance. Acute blood pressure reduction may result in shunting of blood and sudden fetal distress. We therefore investigated the effects of volume expansion and verapamil therapy on uteroplacental and umbilical resistance during treatment of preeclampsia. Materials and Methods: Five severe preeclamptics underwent volume expansion and subsequent vasodilatation with an infusion of verapamil. Invasive hemodynamic monitoring and Doppler ultrasonography were used to study changes in maternal, uterine, and umbilical hemodynamics. Results: Volume expansion and subsequent verapamil therapy was associated with significant changes in maternal hemodynamics without significant change in uteroplacental or umbilical resistance. Uterine artery waveform changes were noted, with disappearance of notching in some cases. Conclusions: Volume expansion and verapamil therapy effectively reduces maternal blood pressure in preeclampsia, without adversely affecting uteroplacental or umbilical artery resistance. Uterine artery waveform changes may be associated with improved fetal outcome. © 1994 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)317-325
Number of pages9
JournalJournal of Clinical Ultrasound
Volume22
Issue number5
DOIs
StatePublished - Jun 1994
Externally publishedYes

Keywords

  • Doppler ultrasonography
  • Hemodynamic changes
  • Preeclampsia
  • Pregnancy
  • Verapamil

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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