TY - JOUR
T1 - The effect of adriamycin and actinomycin D on radiation-induced skin reactions in mouse feet
AU - Leslie Redpath, J.
AU - Colman, Martin
N1 - Funding Information:
Both adriamycin and actinomycin D have been shown to modify the radiation response of cells in culture’.6 and of several normal tissues in experimental animals’ (and references therein). Furthermore, there is considerable clinical evidence for the enhancement of radiation reactions in heart, lung and skin by adriamycin, and in lung and skin by actinomycin D.9 Surprisingly little attention has been paid to the effect of these drugs on radiation-induced skin reactions in experimental animals. Almost 20 years ago, D’Angio et ~1.~c ompared the response of mouse feet to 1000 rad of 250 kVp X-rays to that observed with 1000 rad plus actinomycin D. They noted an earlier and more severe epilation in animals treated with the drug radiation combination. Preliminary studies of Redpath et al.” on the effect of adriamycin on the response of mouse feet to single or fractionated exposures of 6 MeV photons indicated no enhancement of reaction. This paper presents data from a follow-up study with adriamycin and, also, data from tThis study was funded in part by Grant No. 78114 from The University of California Cancer Research Coordinating Committee and Grant No. PDT-125 from the American Cancer Society. Reprint requests to: J. Leslie Redpath, Ph.D. *Institute for Cancer Research.
PY - 1979/4
Y1 - 1979/4
N2 - The effects of adriamycin (10 mg/kg, i.p.) and actinomycin D (0.7 mg/kg, i.p.) on radiation-induced skin reactions in mouse feet have been examined. Drugs were administered either 24 or 2 hr before, or 24 hr after single doses of 6 MeV photons. Split radiation dose experiments were also performed with the drug being administered either 24 or 2 hr before the first radiation dose. A five daily fraction experiment with drug administered 2 hr before the first and third doses was also carried out. In none of these experiments did adriamycin alter the kinetics of appearance, or the severity of, the radiation-induced reaction. Furthermore, drug administered 30 days after the radiation dose, i.e. after the radiation reaction was healed, did not induce any further reaction. These results confirm our previous preliminary observations that adriamycin does not significantly enhance radiation damage to the skin of mouse feet. In the case of actinomycin D no enhancement of skin reaction in single radiation dose experiments was observed. However, in both the split dose and five fraction study a significantly more severe skin reaction was seen in the drug treated animals compared to those treated with radiation alone.
AB - The effects of adriamycin (10 mg/kg, i.p.) and actinomycin D (0.7 mg/kg, i.p.) on radiation-induced skin reactions in mouse feet have been examined. Drugs were administered either 24 or 2 hr before, or 24 hr after single doses of 6 MeV photons. Split radiation dose experiments were also performed with the drug being administered either 24 or 2 hr before the first radiation dose. A five daily fraction experiment with drug administered 2 hr before the first and third doses was also carried out. In none of these experiments did adriamycin alter the kinetics of appearance, or the severity of, the radiation-induced reaction. Furthermore, drug administered 30 days after the radiation dose, i.e. after the radiation reaction was healed, did not induce any further reaction. These results confirm our previous preliminary observations that adriamycin does not significantly enhance radiation damage to the skin of mouse feet. In the case of actinomycin D no enhancement of skin reaction in single radiation dose experiments was observed. However, in both the split dose and five fraction study a significantly more severe skin reaction was seen in the drug treated animals compared to those treated with radiation alone.
KW - Actinomycin D
KW - Adriamycin
KW - Skin reactions
KW - X-ray
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U2 - 10.1016/0360-3016(79)90810-1
DO - 10.1016/0360-3016(79)90810-1
M3 - Article
C2 - 457493
AN - SCOPUS:0018751580
SN - 0360-3016
VL - 5
SP - 483
EP - 486
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
IS - 4
ER -