The effect of adriamycin on radiation damage to mouse lung and skin

J. Leslie Redpath; Raymond M. David; Martin Colman

doi:10.1016/0360-3016(78)90142-6

The effect of adriamycin on radiation damage to mouse lung and skin

J. Leslie Redpath, Raymond M. David, Martin Colman

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Adriamycin (doxorubicin HCl) (10 mg/kg) administered i.p. to C₃H HeJ mice 24 hr before or after thoracic radiation has been found to reduce the LD_{50 40-180} i.e. the dose to kill 50% animals through pulmonary damage, from 1600 rad to 960 rad. A similar dose of Adriamycin administered i.p. 0.5-1 hour before irradiation was found not to enhance the skin reaction of male ICR albino mice feet.

Original language	English (US)
Pages (from-to)	229-232
Number of pages	4
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	4
Issue number	3-4
DOIs	https://doi.org/10.1016/0360-3016(78)90142-6
State	Published - 1978
Externally published	Yes

Keywords

Adriamycin
Lung
Radiation
Skin

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Radiation

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10.1016/0360-3016(78)90142-6

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title = "The effect of adriamycin on radiation damage to mouse lung and skin",

abstract = "Adriamycin (doxorubicin HCl) (10 mg/kg) administered i.p. to C3H HeJ mice 24 hr before or after thoracic radiation has been found to reduce the LD 50 40-180 i.e. the dose to kill 50% animals through pulmonary damage, from 1600 rad to 960 rad. A similar dose of Adriamycin administered i.p. 0.5-1 hour before irradiation was found not to enhance the skin reaction of male ICR albino mice feet.",

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doi = "10.1016/0360-3016(78)90142-6",

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AU - Redpath, J. Leslie

AU - David, Raymond M.

AU - Colman, Martin

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AB - Adriamycin (doxorubicin HCl) (10 mg/kg) administered i.p. to C3H HeJ mice 24 hr before or after thoracic radiation has been found to reduce the LD 50 40-180 i.e. the dose to kill 50% animals through pulmonary damage, from 1600 rad to 960 rad. A similar dose of Adriamycin administered i.p. 0.5-1 hour before irradiation was found not to enhance the skin reaction of male ICR albino mice feet.

KW - Adriamycin

KW - Lung

KW - Radiation

KW - Skin

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The effect of adriamycin on radiation damage to mouse lung and skin

Abstract

Keywords

ASJC Scopus subject areas

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