Adriamycin (doxorubicin HCl) (10 mg/kg) administered i.p. to C3H HeJ mice 24 hr before or after thoracic radiation has been found to reduce the LD 50 40-180 i.e. the dose to kill 50% animals through pulmonary damage, from 1600 rad to 960 rad. A similar dose of Adriamycin administered i.p. 0.5-1 hour before irradiation was found not to enhance the skin reaction of male ICR albino mice feet.
|Original language||English (US)|
|Number of pages||4|
|Journal||International Journal of Radiation Oncology, Biology, Physics|
|State||Published - 1978|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging