The effect of adriamycin on radiation damage to mouse lung and skin

J. Leslie Redpath, Raymond M. David, Martin Colman

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Adriamycin (doxorubicin HCl) (10 mg/kg) administered i.p. to C3H HeJ mice 24 hr before or after thoracic radiation has been found to reduce the LD 50 40-180 i.e. the dose to kill 50% animals through pulmonary damage, from 1600 rad to 960 rad. A similar dose of Adriamycin administered i.p. 0.5-1 hour before irradiation was found not to enhance the skin reaction of male ICR albino mice feet.

Original languageEnglish (US)
Pages (from-to)229-232
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume4
Issue number3-4
DOIs
StatePublished - Jan 1 1978

Keywords

  • Adriamycin
  • Lung
  • Radiation
  • Skin

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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