The effect of adriamycin on radiation damage to mouse lung and skin

J. Leslie Redpath, Raymond M. David, Martin Colman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Adriamycin (doxorubicin HCl) (10 mg/kg) administered i.p. to C3H HeJ mice 24 hr before or after thoracic radiation has been found to reduce the LD 50 40-180 i.e. the dose to kill 50% animals through pulmonary damage, from 1600 rad to 960 rad. A similar dose of Adriamycin administered i.p. 0.5-1 hour before irradiation was found not to enhance the skin reaction of male ICR albino mice feet.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume4
Issue number3-4
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

radiation damage
Doxorubicin
lungs
mice
Radiation
dosage
Lung
Skin
animals
Inbred ICR Mouse
Inbred C3H Mouse
damage
irradiation
Foot
radiation
Thorax

Keywords

  • Adriamycin
  • Lung
  • Radiation
  • Skin

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

The effect of adriamycin on radiation damage to mouse lung and skin. / Redpath, J. Leslie; David, Raymond M.; Colman, Martin.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 4, No. 3-4, 1978, p. 229-232.

Research output: Contribution to journalArticle

Redpath, J. Leslie ; David, Raymond M. ; Colman, Martin. / The effect of adriamycin on radiation damage to mouse lung and skin. In: International Journal of Radiation Oncology, Biology, Physics. 1978 ; Vol. 4, No. 3-4. pp. 229-232.
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