The effect of age on small bowel adaptation and growth after proximal enterectomy

G. J. Poston, R. Saydjari, J. Lawrence, R. W. Alexander, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We examined the effect of age on the adaptive capacity of small bowel mucosa following 60% enterectomy. Two groups of male Fischer 344 rats (3 mo old and 26 mo) underwent either a mid-small bowel transection and reanastomosis (control) or 60% proximal enterectomy beginning at the duodenojejunal junction. Rats were sacrificed at 5, 14, and 21 days after operation, and the mucosa was weighed and assayed for DNA, RNA, protein, and polyamine concentration and content. Ornithine decarboxylase activity was also measured in ileal mucosa at 5 days after surgery. Young rats had completed the adaptive hyperplastic response within 2 weeks after operation by all biochemical measurements; similar adaptation was not seen until 3 weeks after operation in the old rats. We conclude that although the capacity to achieve intestinal adaptation after enterectomy is preserved into old age in rats, this compensatory response is delayed.

Original languageEnglish (US)
JournalJournals of Gerontology
Volume45
Issue number6
StatePublished - 1990
Externally publishedYes

Fingerprint

Mucous Membrane
Growth
Ornithine Decarboxylase
Inbred F344 Rats
Polyamines
Ambulatory Surgical Procedures
RNA
DNA
Proteins

ASJC Scopus subject areas

  • Aging

Cite this

Poston, G. J., Saydjari, R., Lawrence, J., Alexander, R. W., Townsend, C., & Thompson, J. C. (1990). The effect of age on small bowel adaptation and growth after proximal enterectomy. Journals of Gerontology, 45(6).

The effect of age on small bowel adaptation and growth after proximal enterectomy. / Poston, G. J.; Saydjari, R.; Lawrence, J.; Alexander, R. W.; Townsend, Courtney; Thompson, J. C.

In: Journals of Gerontology, Vol. 45, No. 6, 1990.

Research output: Contribution to journalArticle

Poston, GJ, Saydjari, R, Lawrence, J, Alexander, RW, Townsend, C & Thompson, JC 1990, 'The effect of age on small bowel adaptation and growth after proximal enterectomy', Journals of Gerontology, vol. 45, no. 6.
Poston, G. J. ; Saydjari, R. ; Lawrence, J. ; Alexander, R. W. ; Townsend, Courtney ; Thompson, J. C. / The effect of age on small bowel adaptation and growth after proximal enterectomy. In: Journals of Gerontology. 1990 ; Vol. 45, No. 6.
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