The effect of aging on T-regulatory cell frequency in HIV infection

Allan R. Tenorio, John Spritzler, Jeffrey Martinson, Caroline N. Gichinga, Richard B. Pollard, Michael M. Lederman, Robert C. Kalayjian, Alan L. Landay

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV+ subjects had a total T-reg percent that is 2.8% (p = 0.02) higher than among younger HIV+, older HIV- and younger HIV- subjects. In HIV+ subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r = - 0.45, p = 0.002) and Candida (r = - 0.43, p = 0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV+ subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV+ population and may play a role in the accelerated disease progression seen in older HIV-infected persons.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalClinical Immunology
Issue number3
StatePublished - Mar 2009
Externally publishedYes


  • Aging
  • HIV
  • T-regulatory cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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