The effect of aminophylline on cerebral blood flow in patients with chronic obstructive pulmonary disease.

D. L. Bowton, P. T. Alford, B. D. McLees, Donald Prough, D. A. Stump

Research output: Contribution to journalArticle

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Abstract

Aminophylline has been shown to produce a reduction in cerebral blood flow (CBF) in animal models and patients with neurologic symptoms or signs. The effect of aminophylline on regional CBF (rCBF) in patients with chronic obstructive pulmonary disease (COPD) has not previously been reported to our knowledge. We studied the effect of loading and maintenance infusions of aminophylline on CBF in five subjects with moderate to severe COPD. rCBF was determined in eight homologous regions of each cerebral hemisphere at three intervals: (1) baseline; (2) following the IV loading dose of aminophylline (6.0 mg/kg body weight); and (3) early and late in the maintenance infusion (0.5 mg/kg/hr) period. Aminophylline loading caused a 26 percent reduction (p = 0.005) in mean rCBF from 40.6 +/- 5.2 (SD) ml/100 g/min to 30.1 +/- 6.0 ml/100 g/min. A 23 percent reduction (31.5 +/- 6.9 ml/100 g/min) persisted throughout the maintenance phase. Thus, aminophylline, as customarily used in subjects with COPD, is associated with a significant reduction in rCBF.

Original languageEnglish (US)
Pages (from-to)874-877
Number of pages4
JournalChest
Volume91
Issue number6
StatePublished - Jun 1987
Externally publishedYes

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Cerebrovascular Circulation
Aminophylline
Chronic Obstructive Pulmonary Disease
Maintenance
Regional Blood Flow
Cerebrum
Neurologic Manifestations
Animal Models
Body Weight

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bowton, D. L., Alford, P. T., McLees, B. D., Prough, D., & Stump, D. A. (1987). The effect of aminophylline on cerebral blood flow in patients with chronic obstructive pulmonary disease. Chest, 91(6), 874-877.

The effect of aminophylline on cerebral blood flow in patients with chronic obstructive pulmonary disease. / Bowton, D. L.; Alford, P. T.; McLees, B. D.; Prough, Donald; Stump, D. A.

In: Chest, Vol. 91, No. 6, 06.1987, p. 874-877.

Research output: Contribution to journalArticle

Bowton, DL, Alford, PT, McLees, BD, Prough, D & Stump, DA 1987, 'The effect of aminophylline on cerebral blood flow in patients with chronic obstructive pulmonary disease.', Chest, vol. 91, no. 6, pp. 874-877.
Bowton, D. L. ; Alford, P. T. ; McLees, B. D. ; Prough, Donald ; Stump, D. A. / The effect of aminophylline on cerebral blood flow in patients with chronic obstructive pulmonary disease. In: Chest. 1987 ; Vol. 91, No. 6. pp. 874-877.
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