The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia

I. Buhimschi, K. Chwalisz, George Saade, R. Garfield X

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To determine the role of endothelin (ET) in a previously characterized animal model of preeclampsia by studying the effect of a specific ET antagonist, BQ123, on blood pressure (BP). STUDY DESIGN: As previously reported, a preeclampsia-like condition was induced by infusing pregnant rats with the nitric oxide synthase inhibitor, L-NAME. Osmotic minipumps were inserted subcutaneously into timed pregnant Harlan-Sprague-Dawley rats on day 17 of pregnancy (term 22 days). The pumps were loaded to continuously deliver either vehicle (Control group), L-NAME 50 mg/d alone (L-NAME group) or with BQ 0.5 mg/d (L-NAME + BQ/0.5 group). In a similar, but separate experiment, the dose of BQ was increased to 1 mg/d (L-NAME + BQ/1 group). BP was measured with the tailcuff method before pump insertion and daily until postpartum day 2. Data presented as mean ±SE. RESULTS: Except for a decrease on the day following pump insertion, BQ/0.5 had no significant effect on the hypertension induced by L-NAME (Fig. A). At the higher dose however, BQ 123 significantly attenuated the increase in blood pressure induced by L-NAME during most of the study period (Fig. B). CONCLUSION: Endothelin appears to play a role in the hypertension described with the preeclampsia-like condition induced by nitric oxide deficiency in the rat.

Original languageEnglish (US)
JournalActa Diabetologica Latina
Volume176
Issue number1 PART II
StatePublished - 1997
Externally publishedYes

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NG-Nitroarginine Methyl Ester
Pre-Eclampsia
Blood Pressure
Endothelins
Hypertension
Endothelin Receptor Antagonists
Nitric Oxide Synthase
Postpartum Period
Sprague Dawley Rats
Nitric Oxide
Animal Models
Pregnancy
Control Groups

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia. / Buhimschi, I.; Chwalisz, K.; Saade, George; Garfield X, R.

In: Acta Diabetologica Latina, Vol. 176, No. 1 PART II, 1997.

Research output: Contribution to journalArticle

Buhimschi, I. ; Chwalisz, K. ; Saade, George ; Garfield X, R. / The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia. In: Acta Diabetologica Latina. 1997 ; Vol. 176, No. 1 PART II.
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