The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro

Gui Fang Jin, Yan Shi Guo, Edward R. Smith, Clifford W. Houston

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic function of mouse phagocytes. BBS-related peptides, gastrin-releasing peptides (GRP)-27, GRP-14, GRP-10 and neuromedin B, also induced similar CL responses compared with BBS. The CL response elicited by BBS was depressed dramatically by various concentration of EGTA (a Ca++ chelator), indicating that a Ca++ pathway may play a key role in the BBS-stimulated CL response.

Original languageEnglish (US)
Pages (from-to)393-396
Number of pages4
JournalPeptides
Volume11
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Bombesin
Phagocytes
Chemiluminescence
Luminescence
Peptides
Gastrin-Releasing Peptide
Luminol
Zymosan
Macrophages
Egtazic Acid
Chelating Agents
In Vitro Techniques
Neutrophils

Keywords

  • Bombesin
  • Ca
  • Chemiluminescence
  • GRP
  • Neuromedin B
  • Phagocytic cells

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro. / Jin, Gui Fang; Guo, Yan Shi; Smith, Edward R.; Houston, Clifford W.

In: Peptides, Vol. 11, No. 2, 1990, p. 393-396.

Research output: Contribution to journalArticle

Jin, Gui Fang ; Guo, Yan Shi ; Smith, Edward R. ; Houston, Clifford W. / The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro. In: Peptides. 1990 ; Vol. 11, No. 2. pp. 393-396.
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