The effect of burn on serum concentrations of sclerostin and FGF23

Gordon L. Klein, David Herndon, Phuong T. Le, Clark R. Andersen, Debra Benjamin, Clifford J. Rosen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Severe burn results in acute bone resorption followed by an adynamic state, most likely due to changes brought about by the inflammatory and glucocorticoid responses to the injury. There is a consequent increase in annual extrapolated fracture incidence in children. While osteoblasts have been reported to disappear from the bone surface and stem cell differentiation into osteoblasts is impaired, the effect of burns on osteocyte function is unknown. We measured serum concentrations of two osteocyte proteins, sclerostin and fibroblast growth factor (FGF)-23 between 6 and 60 days post-burn in pediatric patients, ages 5-18 years who had participated in a randomized controlled double-blind study of acute administration of pamidronate to prevent the resorptive bone loss. While FGF-23 was undetectable in all samples, the plot of sclerostin concentration versus time post-burn yielded a statistically significant difference between slopes, -2.5 in the placebo control group and +3.5 in the group receiving pamidronate, p = 0.016 by ANCOVA. The FGF23 data suggest that osteocytes may be apoptotic, although the sclerostin data may indicate partial preservation of osteocyte function in subjects receiving pamidronate or an ectopic source of sclerostin.

Original languageEnglish (US)
Pages (from-to)1532-1535
Number of pages4
JournalBurns
Volume41
Issue number7
DOIs
StatePublished - Nov 1 2015

Fingerprint

pamidronate
Osteocytes
Burns
Serum
Osteoblasts
Bone and Bones
Bone Resorption
Double-Blind Method
Glucocorticoids
Cell Differentiation
Stem Cells
Placebos
Pediatrics
Control Groups
Incidence
Wounds and Injuries
Proteins

Keywords

  • Burns
  • FGF23
  • Osteocytes
  • Sclerostin

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Klein, G. L., Herndon, D., Le, P. T., Andersen, C. R., Benjamin, D., & Rosen, C. J. (2015). The effect of burn on serum concentrations of sclerostin and FGF23. Burns, 41(7), 1532-1535. https://doi.org/10.1016/j.burns.2015.04.001

The effect of burn on serum concentrations of sclerostin and FGF23. / Klein, Gordon L.; Herndon, David; Le, Phuong T.; Andersen, Clark R.; Benjamin, Debra; Rosen, Clifford J.

In: Burns, Vol. 41, No. 7, 01.11.2015, p. 1532-1535.

Research output: Contribution to journalArticle

Klein, GL, Herndon, D, Le, PT, Andersen, CR, Benjamin, D & Rosen, CJ 2015, 'The effect of burn on serum concentrations of sclerostin and FGF23', Burns, vol. 41, no. 7, pp. 1532-1535. https://doi.org/10.1016/j.burns.2015.04.001
Klein GL, Herndon D, Le PT, Andersen CR, Benjamin D, Rosen CJ. The effect of burn on serum concentrations of sclerostin and FGF23. Burns. 2015 Nov 1;41(7):1532-1535. https://doi.org/10.1016/j.burns.2015.04.001
Klein, Gordon L. ; Herndon, David ; Le, Phuong T. ; Andersen, Clark R. ; Benjamin, Debra ; Rosen, Clifford J. / The effect of burn on serum concentrations of sclerostin and FGF23. In: Burns. 2015 ; Vol. 41, No. 7. pp. 1532-1535.
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