The effect of burn trauma on lipid and glucose metabolism: Implications for insulin sensitivity

Robert P. Clayton, David Herndon, Nicola Abate, Craig Porter

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Severe burns represent a unique form of trauma in terms of the magnitude and persistence of the stress response they incur. Given advances in acute burn care in the last quarter of a century and the resultant reduction in mortality rates, even for those with massive burns, greater emphasis is now placed on understanding the metabolic stress response to severe burn trauma in order to devise strategies that promote recovery and reduce morbidity. Derangements in metabolism including protein and lipid redistribution and altered glucose handling are hallmarks of the pathophysiological response to burn trauma. In this review article, we aim to distill and discuss the current literature concerning the effect of burn trauma on lipid and glucose metabolism. Furthermore, we will discuss the implications of altered lipid metabolism with regards to insulin sensitivity and glucose control, while discussing the utility of agents and strategies aimed at restoring normal lipid and glucose metabolism in burned patients.

Original languageEnglish (US)
Pages (from-to)713-723
Number of pages11
JournalJournal of Burn Care and Research
Volume39
Issue number5
DOIs
StatePublished - Jan 1 2018

Fingerprint

Lipid Metabolism
Insulin Resistance
Glucose
Wounds and Injuries
Burns
Physiological Stress
Morbidity
Lipids
Mortality
Proteins

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

Cite this

The effect of burn trauma on lipid and glucose metabolism : Implications for insulin sensitivity. / Clayton, Robert P.; Herndon, David; Abate, Nicola; Porter, Craig.

In: Journal of Burn Care and Research, Vol. 39, No. 5, 01.01.2018, p. 713-723.

Research output: Contribution to journalArticle

Clayton, Robert P. ; Herndon, David ; Abate, Nicola ; Porter, Craig. / The effect of burn trauma on lipid and glucose metabolism : Implications for insulin sensitivity. In: Journal of Burn Care and Research. 2018 ; Vol. 39, No. 5. pp. 713-723.
@article{20d47d46b5894d24836417d7bed65bf1,
title = "The effect of burn trauma on lipid and glucose metabolism: Implications for insulin sensitivity",
abstract = "Severe burns represent a unique form of trauma in terms of the magnitude and persistence of the stress response they incur. Given advances in acute burn care in the last quarter of a century and the resultant reduction in mortality rates, even for those with massive burns, greater emphasis is now placed on understanding the metabolic stress response to severe burn trauma in order to devise strategies that promote recovery and reduce morbidity. Derangements in metabolism including protein and lipid redistribution and altered glucose handling are hallmarks of the pathophysiological response to burn trauma. In this review article, we aim to distill and discuss the current literature concerning the effect of burn trauma on lipid and glucose metabolism. Furthermore, we will discuss the implications of altered lipid metabolism with regards to insulin sensitivity and glucose control, while discussing the utility of agents and strategies aimed at restoring normal lipid and glucose metabolism in burned patients.",
author = "Clayton, {Robert P.} and David Herndon and Nicola Abate and Craig Porter",
year = "2018",
month = "1",
day = "1",
doi = "10.1093/jbcr/irx047",
language = "English (US)",
volume = "39",
pages = "713--723",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - The effect of burn trauma on lipid and glucose metabolism

T2 - Implications for insulin sensitivity

AU - Clayton, Robert P.

AU - Herndon, David

AU - Abate, Nicola

AU - Porter, Craig

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Severe burns represent a unique form of trauma in terms of the magnitude and persistence of the stress response they incur. Given advances in acute burn care in the last quarter of a century and the resultant reduction in mortality rates, even for those with massive burns, greater emphasis is now placed on understanding the metabolic stress response to severe burn trauma in order to devise strategies that promote recovery and reduce morbidity. Derangements in metabolism including protein and lipid redistribution and altered glucose handling are hallmarks of the pathophysiological response to burn trauma. In this review article, we aim to distill and discuss the current literature concerning the effect of burn trauma on lipid and glucose metabolism. Furthermore, we will discuss the implications of altered lipid metabolism with regards to insulin sensitivity and glucose control, while discussing the utility of agents and strategies aimed at restoring normal lipid and glucose metabolism in burned patients.

AB - Severe burns represent a unique form of trauma in terms of the magnitude and persistence of the stress response they incur. Given advances in acute burn care in the last quarter of a century and the resultant reduction in mortality rates, even for those with massive burns, greater emphasis is now placed on understanding the metabolic stress response to severe burn trauma in order to devise strategies that promote recovery and reduce morbidity. Derangements in metabolism including protein and lipid redistribution and altered glucose handling are hallmarks of the pathophysiological response to burn trauma. In this review article, we aim to distill and discuss the current literature concerning the effect of burn trauma on lipid and glucose metabolism. Furthermore, we will discuss the implications of altered lipid metabolism with regards to insulin sensitivity and glucose control, while discussing the utility of agents and strategies aimed at restoring normal lipid and glucose metabolism in burned patients.

UR - http://www.scopus.com/inward/record.url?scp=85055533100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055533100&partnerID=8YFLogxK

U2 - 10.1093/jbcr/irx047

DO - 10.1093/jbcr/irx047

M3 - Article

AN - SCOPUS:85055533100

VL - 39

SP - 713

EP - 723

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 5

ER -