The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model

Gloria G. Box, Ronald Lindsey, Lukas Curylo, Theodore Miclau, Jerry W. Alexander, Stephan M. Perren

Research output: Contribution to journalArticle

Abstract

Bone grafting of osseous defects is often delayed to minimize the risk of infection, however, the effect of this delay on defect healing is not clear. Unilateral oblong unicortical diaphyseal femoral defects (30×4.5 mm) were created in 3 groups of 18 adult canines that were grafted with autogenous bone immediately, at 2 weeks, and at 6 weeks. After an 8-week healing period, paired femurs, which consisted of defect versus intact specimens, were assessed by biomechanical testing and microradiography. No differences were demonstrated biomechanically or radiographically between the healing defects with immediate versus delayed bone grafting. This study suggests that within the first 6 weeks postoperatively osseous defects can be grafted with autologous bone without adversely affecting bone graft incorporation.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalOrthopedics
Volume26
Issue number3
StatePublished - Mar 1 2003
Externally publishedYes

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Bone Transplantation
Canidae
Bone and Bones
Microradiography
Thigh
Femur
Transplants
Infection

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Box, G. G., Lindsey, R., Curylo, L., Miclau, T., Alexander, J. W., & Perren, S. M. (2003). The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model. Orthopedics, 26(3), 311-315.

The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model. / Box, Gloria G.; Lindsey, Ronald; Curylo, Lukas; Miclau, Theodore; Alexander, Jerry W.; Perren, Stephan M.

In: Orthopedics, Vol. 26, No. 3, 01.03.2003, p. 311-315.

Research output: Contribution to journalArticle

Box, GG, Lindsey, R, Curylo, L, Miclau, T, Alexander, JW & Perren, SM 2003, 'The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model', Orthopedics, vol. 26, no. 3, pp. 311-315.
Box GG, Lindsey R, Curylo L, Miclau T, Alexander JW, Perren SM. The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model. Orthopedics. 2003 Mar 1;26(3):311-315.
Box, Gloria G. ; Lindsey, Ronald ; Curylo, Lukas ; Miclau, Theodore ; Alexander, Jerry W. ; Perren, Stephan M. / The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model. In: Orthopedics. 2003 ; Vol. 26, No. 3. pp. 311-315.
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