The effect of deletion of a conserved 11 nucleotide sequence on mouse hepatitis virus RNA replication

J. F. Repass; S. Makino

doi:10.1007/978-1-4615-5331-1_31

The effect of deletion of a conserved 11 nucleotide sequence on mouse hepatitis virus RNA replication

J. F. Repass, S. Makino

Research output: Contribution to journal › Article › peer-review

Abstract

A conserved 11 nt sequence present at near the 3' end of mouse hepatitis virus (MHV) genomic RNA binds to host proteins and is important for MHV RNA replication (Yu and Leibowitz, 1995). To better understand the role of this 11 nt sequence in positive-strand MHV RNA replication, we examined whether positive-strand MHV DI RNAs from negative-strand DI RNA transcripts lacking the 11 nt sequence were synthesized in MHV-infected cells. Positive-strand DI RNAs did not accumulate efficiently, indicating that the conserved 11 nt sequence was necessary for positive-strand MHV RNA synthesis.

Original language	English (US)
Pages (from-to)	247-252
Number of pages	6
Journal	Advances in experimental medicine and biology
Volume	440
DOIs	https://doi.org/10.1007/978-1-4615-5331-1_31
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4615-5331-1_31

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abstract = "A conserved 11 nt sequence present at near the 3' end of mouse hepatitis virus (MHV) genomic RNA binds to host proteins and is important for MHV RNA replication (Yu and Leibowitz, 1995). To better understand the role of this 11 nt sequence in positive-strand MHV RNA replication, we examined whether positive-strand MHV DI RNAs from negative-strand DI RNA transcripts lacking the 11 nt sequence were synthesized in MHV-infected cells. Positive-strand DI RNAs did not accumulate efficiently, indicating that the conserved 11 nt sequence was necessary for positive-strand MHV RNA synthesis.",

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AB - A conserved 11 nt sequence present at near the 3' end of mouse hepatitis virus (MHV) genomic RNA binds to host proteins and is important for MHV RNA replication (Yu and Leibowitz, 1995). To better understand the role of this 11 nt sequence in positive-strand MHV RNA replication, we examined whether positive-strand MHV DI RNAs from negative-strand DI RNA transcripts lacking the 11 nt sequence were synthesized in MHV-infected cells. Positive-strand DI RNAs did not accumulate efficiently, indicating that the conserved 11 nt sequence was necessary for positive-strand MHV RNA synthesis.

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JF - Advances in Experimental Medicine and Biology

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The effect of deletion of a conserved 11 nucleotide sequence on mouse hepatitis virus RNA replication

Abstract

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