The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries

R. Y Declan Fleming, David Herndon, Smita Vaidya, Ray J. Nichols, Manu H. Desai, Randi L. Rutan, J. Paul Waymack

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. Surgical procedures result in blood loss that can require replacement transfusions. Such therapy may result in multiple adverse sequelae, including transmission of infectious diseases and immune impairment. Alternative therapies are therefore desirable. Methods. We evaluated the ability of recombinant human erythropoietin (rEPO) to increase red blood cell production in both normal healthy volunteers and patients with burn injuries. The effect of rEPO on immune function in the volunteers was also evaluated. The volunteers received 150 units/kg rEPO daily for 7 days, with immune function and hematopoiesis assayed on days 0, 7, and 14. The patients with burn injuries received either 500 units/kg/day rEPO with iron supplementation or merely the iron. Results. rEPO increased erythropoiesis in both the volunteers and the patients with burn injuries. Failure to provide iron supplementation to the volunteers resulted in significant depletion of iron stores with a concomitant impairment in immune function that paralleled the iron depletion. Conclusions. rEPO therapy offers the potential to increase red blood cell production in surgical patients. Failure to provide iron supplementation in patients receiving rEPO can lead to a rapid depletion of iron stores and may contribute to an immune dysfunction.

Original languageEnglish (US)
Pages (from-to)424-432
Number of pages9
JournalSurgery
Volume112
Issue number2
StatePublished - 1992

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Erythropoietin
Healthy Volunteers
Iron
Pediatrics
Wounds and Injuries
Volunteers
Erythrocytes
Infectious Disease Transmission
Erythropoiesis
Hematopoiesis
Complementary Therapies
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Fleming, R. Y. D., Herndon, D., Vaidya, S., Nichols, R. J., Desai, M. H., Rutan, R. L., & Waymack, J. P. (1992). The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries. Surgery, 112(2), 424-432.

The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries. / Fleming, R. Y Declan; Herndon, David; Vaidya, Smita; Nichols, Ray J.; Desai, Manu H.; Rutan, Randi L.; Waymack, J. Paul.

In: Surgery, Vol. 112, No. 2, 1992, p. 424-432.

Research output: Contribution to journalArticle

Fleming, RYD, Herndon, D, Vaidya, S, Nichols, RJ, Desai, MH, Rutan, RL & Waymack, JP 1992, 'The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries', Surgery, vol. 112, no. 2, pp. 424-432.
Fleming RYD, Herndon D, Vaidya S, Nichols RJ, Desai MH, Rutan RL et al. The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries. Surgery. 1992;112(2):424-432.
Fleming, R. Y Declan ; Herndon, David ; Vaidya, Smita ; Nichols, Ray J. ; Desai, Manu H. ; Rutan, Randi L. ; Waymack, J. Paul. / The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries. In: Surgery. 1992 ; Vol. 112, No. 2. pp. 424-432.
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