The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity

Yoseph A. Mekori, Edward M. Bender, Ramon Zapata Sirvent, John F. Hansbrough, Henry N. Claman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We studied the effects of H1 and H2 histamine receptor antagonists on down regulation of contact sensitivity (CS) to dinitrofluorobenzene (DNFB). Two H2 receptor antagonists, cimetidine and ranitidine, reversed the nonspecific immunosuppression of CS induced by burns. On the other hand, these two drugs did not affect the antigen-specific suppressor T cell-mediated tolerance to DNFB induced by dinitrobenzene sulfonic acid. Two H1 antagonists did not affect the down regulation of CS induced by either tolerance or burning. The differential sensitivities to histamine2-receptor antagonists indicate that the mechanisms for nonspecific burn-induced immunosuppression are different from those for hapten-specific tolerance to DNFB.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Volume76
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Dinitrofluorobenzene
Histamine Receptors
Histamine Antagonists
Contact Dermatitis
Burns
Immunosuppression
Down-Regulation
Dinitrobenzenes
Histamine H1 Antagonists
Histamine H2 Antagonists
Histamine H2 Receptors
Ranitidine
Sulfonic Acids
Haptens
Cimetidine
T-Lymphocytes
Antigens
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity. / Mekori, Yoseph A.; Bender, Edward M.; Zapata Sirvent, Ramon; Hansbrough, John F.; Claman, Henry N.

In: The Journal of Allergy and Clinical Immunology, Vol. 76, No. 1, 01.01.1985, p. 90-96.

Research output: Contribution to journalArticle

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