The effect of hypermagnesemia on serum levels of osteocalcin in an animal model

F. H. Wians, D. M. Strickland, G. D. Hankins, R. R. Snyder

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Using a pregnant goat (Capra hircus) model to study the in vivo effects of hypermagnesemia on serum osteocalcin concentration, magnesium sulfate infusion has been shown to increase circulating levels of osteocalcin. At 2 h after the administration of magnesium sulfate, a 98% increase in Mg2+ concentration over the basal level resulted in: a 38% increase in serum osteocalcin concentration over baseline; a 22% decrease in PTH concentration, and no change in total and ionized calcium concentrations. These in vivo data support previous in vitro results demonstrating that Mg2+ is a potent inhibitor of osteocalcin binding to hydroxyapatite.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalMagnesium and Trace Elements
Volume9
Issue number1
StatePublished - Jun 26 1990

ASJC Scopus subject areas

  • Biochemistry

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