The effect of hypermagnesemia on serum levels of osteocalcin in an animal model

F. H. Wians, D. M. Strickland, Gary Hankins, Russell Snyder

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Using a pregnant goat (Capra hircus) model to study the in vivo effects of hypermagnesemia on serum osteocalcin concentration, magnesium sulfate infusion has been shown to increase circulating levels of osteocalcin. At 2 h after the administration of magnesium sulfate, a 98% increase in Mg2+ concentration over the basal level resulted in: a 38% increase in serum osteocalcin concentration over baseline; a 22% decrease in PTH concentration, and no change in total and ionized calcium concentrations. These in vivo data support previous in vitro results demonstrating that Mg2+ is a potent inhibitor of osteocalcin binding to hydroxyapatite.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalMagnesium and Trace Elements
Volume9
Issue number1
StatePublished - 1990
Externally publishedYes

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Osteocalcin
Animals
Animal Models
Magnesium Sulfate
Serum
Goats
Durapatite
Calcium

ASJC Scopus subject areas

  • Biochemistry

Cite this

The effect of hypermagnesemia on serum levels of osteocalcin in an animal model. / Wians, F. H.; Strickland, D. M.; Hankins, Gary; Snyder, Russell.

In: Magnesium and Trace Elements, Vol. 9, No. 1, 1990, p. 28-35.

Research output: Contribution to journalArticle

Wians, F. H. ; Strickland, D. M. ; Hankins, Gary ; Snyder, Russell. / The effect of hypermagnesemia on serum levels of osteocalcin in an animal model. In: Magnesium and Trace Elements. 1990 ; Vol. 9, No. 1. pp. 28-35.
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