The effect of hypohydration on endothelial function in young healthy adults

Giannis Arnaoutis, Stavros A. Kavouras, Nikolaos Stratakis, Marita Likka, Asimina Mitrakou, Christos Papamichael, Labros S. Sidossis, Kimon Stamatelopoulos

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. Methods: Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m−2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of −2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. Results: Hypohydration by −1.9 ± 0.1 % of body mass resulted in decreased plasma volume by −3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg−1 (P <0.001). FMD as a response to hypohydration decreased by −26.8 ± 3.9 % (P <0.05). Conclusion: The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalEuropean Journal of Nutrition
DOIs
StateAccepted/In press - Feb 10 2016
Externally publishedYes

Fingerprint

Dilatation
Young Adult
Cardiovascular Diseases
Exercise
Plasma Volume
Causality
Osmolar Concentration
Cross-Over Studies
Walking
Cause of Death
Pathology
Diet
Weights and Measures
Water

Keywords

  • Cardiovascular disease
  • Dehydration
  • Endothelial
  • Flow-mediated dilation
  • Fluid balance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Arnaoutis, G., Kavouras, S. A., Stratakis, N., Likka, M., Mitrakou, A., Papamichael, C., ... Stamatelopoulos, K. (Accepted/In press). The effect of hypohydration on endothelial function in young healthy adults. European Journal of Nutrition, 1-7. https://doi.org/10.1007/s00394-016-1170-8

The effect of hypohydration on endothelial function in young healthy adults. / Arnaoutis, Giannis; Kavouras, Stavros A.; Stratakis, Nikolaos; Likka, Marita; Mitrakou, Asimina; Papamichael, Christos; Sidossis, Labros S.; Stamatelopoulos, Kimon.

In: European Journal of Nutrition, 10.02.2016, p. 1-7.

Research output: Contribution to journalArticle

Arnaoutis, G, Kavouras, SA, Stratakis, N, Likka, M, Mitrakou, A, Papamichael, C, Sidossis, LS & Stamatelopoulos, K 2016, 'The effect of hypohydration on endothelial function in young healthy adults', European Journal of Nutrition, pp. 1-7. https://doi.org/10.1007/s00394-016-1170-8
Arnaoutis G, Kavouras SA, Stratakis N, Likka M, Mitrakou A, Papamichael C et al. The effect of hypohydration on endothelial function in young healthy adults. European Journal of Nutrition. 2016 Feb 10;1-7. https://doi.org/10.1007/s00394-016-1170-8
Arnaoutis, Giannis ; Kavouras, Stavros A. ; Stratakis, Nikolaos ; Likka, Marita ; Mitrakou, Asimina ; Papamichael, Christos ; Sidossis, Labros S. ; Stamatelopoulos, Kimon. / The effect of hypohydration on endothelial function in young healthy adults. In: European Journal of Nutrition. 2016 ; pp. 1-7.
@article{a71b64d21aae489580b23372f444b985,
title = "The effect of hypohydration on endothelial function in young healthy adults",
abstract = "Purpose: Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. Methods: Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m−2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of −2 {\%} of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. Results: Hypohydration by −1.9 ± 0.1 {\%} of body mass resulted in decreased plasma volume by −3.5 ± 1.8 {\%} and increased plasma osmolality by 9 ± 2 mmol kg−1 (P <0.001). FMD as a response to hypohydration decreased by −26.8 ± 3.9 {\%} (P <0.05). Conclusion: The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.",
keywords = "Cardiovascular disease, Dehydration, Endothelial, Flow-mediated dilation, Fluid balance",
author = "Giannis Arnaoutis and Kavouras, {Stavros A.} and Nikolaos Stratakis and Marita Likka and Asimina Mitrakou and Christos Papamichael and Sidossis, {Labros S.} and Kimon Stamatelopoulos",
year = "2016",
month = "2",
day = "10",
doi = "10.1007/s00394-016-1170-8",
language = "English (US)",
pages = "1--7",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "D. Steinkopff-Verlag",

}

TY - JOUR

T1 - The effect of hypohydration on endothelial function in young healthy adults

AU - Arnaoutis, Giannis

AU - Kavouras, Stavros A.

AU - Stratakis, Nikolaos

AU - Likka, Marita

AU - Mitrakou, Asimina

AU - Papamichael, Christos

AU - Sidossis, Labros S.

AU - Stamatelopoulos, Kimon

PY - 2016/2/10

Y1 - 2016/2/10

N2 - Purpose: Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. Methods: Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m−2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of −2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. Results: Hypohydration by −1.9 ± 0.1 % of body mass resulted in decreased plasma volume by −3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg−1 (P <0.001). FMD as a response to hypohydration decreased by −26.8 ± 3.9 % (P <0.05). Conclusion: The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.

AB - Purpose: Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. Methods: Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m−2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of −2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. Results: Hypohydration by −1.9 ± 0.1 % of body mass resulted in decreased plasma volume by −3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg−1 (P <0.001). FMD as a response to hypohydration decreased by −26.8 ± 3.9 % (P <0.05). Conclusion: The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.

KW - Cardiovascular disease

KW - Dehydration

KW - Endothelial

KW - Flow-mediated dilation

KW - Fluid balance

UR - http://www.scopus.com/inward/record.url?scp=84957652753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957652753&partnerID=8YFLogxK

U2 - 10.1007/s00394-016-1170-8

DO - 10.1007/s00394-016-1170-8

M3 - Article

SP - 1

EP - 7

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -